Background The A2A adenosine receptor is a prototypical G proteincoupled receptor. It is expressed in a wide variety of cells including as different types as neurons, platelets, cells of the immune system and muscle. The A2A receptor has an unusually long C-terminus (of >120 residues), which for the most part is dispensable for coupling to Gs. This C-terminus turned out to be the docking site f...

i Foreword In the last semester of the study of Business Mathematics and Informatics at the vrije Universiteit a nal term project has to be performed outside of the university. This paper is the report of my project. The project was a research project at the CWI in Amsterdam, in the research group Software Engineering 4, which is concerned with Evolutionary Algorithms and Applied Algorithmics. ...

Hans Arno Jacobsen Joachim Weisbrod Berkeley Initiative in Soft Computing Institut f ur Programmstrukturen und Datenorganisation University of California Universitat Karlsruhe Berkeley, CA 94720-1776 USA Deutschland [email protected] [email protected] Abstract The conceptual framework of a hybrid control system architecture is brie y motivated. It employs neural and ...

To study erythropoiesis and anemia, one must have a firm foundation of indices that accurately measure red blood cell production and destruction. This paper, authored by hematology legends Arno G. Motulsky and Clement A. Finch, provides that foundation. Using methods that would not be approved in today's environment, the authors studied a cohort of normal healthy patients and an equal number of...

Evidence-based medicine is described as “the conscientious, explicit and judicious use of current best evidence in making decisions about individual patients.”1 The evidence evaluation process summarized in this supplement was designed to ensure the review of all available evidence pertaining to resuscitation. Many aspects of the resuscitation process create unique challenges for the design of ...

Persistent Scatterer Interferometry (PSI) has been widely used for landslide studies in recent years. This paper investigated the spatial patterns of PSI point targets and landslide occurrences in the Arno River basin in Central Italy. The main purpose is to analyze whether spatial patterns of Persistent Scatterers (PS) can be recognized as indicators of landslide occurrences throughout the who...