AIM This study was designed to evaluate the impact of N-acetyltransferase 2 (NAT2, substrate: aromatic amines) in painters with bladder cancer and controls. BACKGROUND Until the beginning of the 1960s, painters in Germany have used, among others, azo dyes based on carcinogenic aromatic amines. MATERIALS AND METHODS Sixteen painters with bladder cancer and 26 healthy painters (controls) who...

N-Arylated aliphatic and aromatic amines are important substituents in many biologically active compounds. In the last few years, transition-metal-mediated N-aryl bond formation has become a standard procedure for the introduction of amines into aromatic systems. While N-arylation of simple aromatic halides by simple amines works with many of the described methods in high yield, the reactions m...

The paper deals with the curing behaviour of diglycidyl ether of bisphenol-A (DGEBA) using three novel multifunctional aromatic amines having phosphine oxide and amide-acid linkages. The amines were prepared by reacting tris(3-aminophenyl)phosphine oxide (TAP) with 1,2,4,5-benzenetetracarboxylic acid anhydride (P)/4,4-(hexafluoroisopropylidene)diphthalic acid anhydride (F)/3,3,4,4-benzophenonet...

An one-pot method has been developed for the synthesis of azo dyes via sequential diazotization–diazo coupling of aromatic amines with coupling agents at room temperature in the presence of Bi(NO3)3. 5H2O. Short reaction times, high yields, a clean process, simple methodology, easy work-up and green ‎conditions are advantages of this protocol.‎

A mild and efficient synthesis of polysubstituted dihydro-2-oxypyrroles has been developed for the one-pot, four-component domino condensation of dialkyl acetylenedicarboxylate, formaldehyde and aromatic amines using Vanadium (V) oxide as the catalyst at ambient temperature. The use of Vanadium (V) oxide makes this process simple, more convenient, and environmentally friendly.

Azoproteins, obtained by the coupling of diazonium ions with the histidyl, tyrosyl, and lysyl groups of proteins, have continued to be materials of utility since their early investigation (1). The ease with which proteins can be modified by this procedure, the variety of aromatic amines that can be used, and the correlation that can be made between the chemical structure of the introduced group...

I would like to consider the problem of chemical carcinogenesis arising from exposure to certain aromatic amines as a basis for my remarks about the predictive value for man of data obtained in other species and biological systems. This example was chosen because it illustrates the complexity of extrapolation very well, and there is new knowledge derived from a variety of disciplines including ...

Aromatic amines, such as benzidine and 3,3'-dichlorobenzidine (DCB), are part of the dyes and pigments manufacturing process. The prolonged use of these carcinogenic chemicals in the past generation has introduced a significant amount of contamination to the environment. Their persistency in several mediums has sparked a number of studies in an attempt to develop predictive tools of their fate ...

Working Group Members Tania Carreón-Valencia, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA King-Thom Chung, Department of Biology, University of Memphis, Memphis, TN 38152, USA Silvia de Sanjosé, Unit of Infections and Cancer, Programme of Research in Cancer Epidemiology, Catalan Institute of Oncology, E-08907 L’Hos...

FeCl3.6H2O was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in EtOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and easy work-up. The structures o...