background and objective: the present study aimed to assess the role of magnesium sulfate (mgso4) sup-plementation after cardiac surgery in pediatric patients, evaluating the incidence of cardiac complications, such as arrhythmia. methods: in this study, 105 children scheduled for elective cardiac surgery were randomly divided into 3 groups. the first group, as the placebo group, received salin...

In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) ...

t one time, patients with acute myocardial infarction (AMI) would have has as poor a prognosis as fatal arrhythmia, cardiac rupture or left ventricular dysfunction. In modern countries, mortality after AMI has been greatly decreased by developments in coronary revascularization, antiarrhythmic agents and the treatment of hypertension and congestive heart failure using angiotensin-converting enz...

Atrial fibrillation (AF) after cardiac surgery remains a common problem, resulting in prolonged hospital stays and added morbidity for a substantial proportion of patients.1 Although traditional therapies with antiarrhythmic agents can suppress this common arrhythmia in nearly half of all cases, generally 1 in 10 of all cardiac surgery patients will have AF despite the best available therapies,...

BACKGROUND Time-domain analysis of the P-wave in signal-averaged ECG (SA-ECG) recorded from chest leads is an accepted method for evaluating the inhomogeneity of atrial excitation, predictive for atrial arrhythmias. The aim of the study was to determine the value of the SA-ECG technique for intraatrial signal processing. Additional aims were to evaluate the correlation between SA-ECG parameters...

BACKGROUND We previously demonstrated that treatment with antiarrhythmic drugs (AADs) during the first 6 weeks after atrial fibrillation (AF) ablation reduces the incidence of clinically significant atrial arrhythmias and need for cardioversion or hospitalization for arrhythmia management. Whether early rhythm suppression decreases longer-term arrhythmia recurrence is unknown. We now report the...

This study was conducted to determine the effects of clofilium phosphate and bretylium tosylate on ventricular defibrillation threshold. Dogs were anesthetized with pentobarbital and subjected to repeated fibrillation-defibrillation episodes. Defibrillation thresholds were determined at 15-min intervals, using underdamped 5--6 msec sinusoidal current shocks, from 30 min before drug injection to...

The electrical storm (ES) is defined as a state of electrical instability with three or more sustained ventricular arrhythmias (VAs) occurring within twenty-four hours, which needs intravenous antiarrhythmic medications and frequent defibrillation. Recently, radiofrequency catheter ablation evolved as a sole therapy to terminate ES in patients with ICD, and the survival has been reported to be ...

A six new analogs of MG-1(S), 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, with adrenolytic properties were tested for electrocardiographic and antiarrhythmic activity in model ventricular arrhythmias associated with coronary artery occlusion and reperfusion in the non-working isolated perfused rat heart and additionally in barium chloride-induced arrhythmia in vivo. All tes...

BACKGROUND Because the relative efficacy of antiarrhythmic agents on halothane-epinephrine arrhythmias has not been well characterized, this study was undertaken to comparatively evaluate the antiarrhythmic action of Na(+)-, K(+)- and Ca(2+)-channel blockers on epinephrine-induced ventricular arrhythmias during halothane anesthesia in rats. METHODS Rats were anesthetized at random with either...