We report two cases of meningitis which developed after combined spinal-extradural procedures for obstetric analgesia. The first case was thought to be caused by aseptic or chemical meningitis and the second was a case of bacterial meningitis in a patient who also received an extradural blood patch. It is important that meningitis is considered as a differential diagnosis in patients who presen...

Introduction: The early presentation of bacterial meningitis and aseptic are similar however treatment outcome different. Bacterial Meningitis Score helps to differentiate from meningitis.
 Aims: To evaluate score as clinical prediction rule in children with acute Methods: This was a hospital based prospective study done at pediatric department Nepalgunj Medical College, Nepalgunj, tertiar...

BACKGROUND Pediatric meningitis remains a common cause of childhood morbidity and mortality in developing countries. Knowledge of the causative organisms in a region is of importance in guiding empiric antibiotic regimes and immunization schedules assisting decisions on primary health-care interventions. METHODS This retrospective review of 557 meningitis cases represents a third pediatric su...

OBJECTIVE To evaluate the diagnostic usefulness of cerebral spinal fluid (CSF) cellularity, protein, neutrophils, glucose and lactate for detection of postoperative bacterial meningitis. METHOD This prospective study was conducted in 28 postoperative neurosurgical patients from 2002 to 2005 at University of São Paulo. The CSF markers were plotted in a receiver operating characteristic (ROC) c...

Cerebrospinal fluid (CSF) lactate assay has been a subject of research since 1925. A systematic review by Huy and colleagues in the previous issue of Critical Care summarizes data from 25 studies evaluating the role of CSF lactate in the differential diagnosis between acute bacterial and aseptic meningitis. The authors concluded that CSF lactate is a good single indicator and a better marker co...

We previously demonstrated that discontinuing presumptive antibiotic treatment in cases of negative conventional cultures is safe and effective for patients with postoperative aseptic meningitis (PAM). Here, we prospectively investigated 32 patients with postoperative meningitis. All 26 patients with PAM diagnosed on the basis of conventional cultures demonstrated negative 16S rRNA PCR results....

The patient was a 50-year-old woman who had had frequency of urination and numbness of the left side of the trunk for a few years. Neurologic examination showed slight anisocoria (right > left), asymmetry of muscle stretch reflex (right > left) in both upper and lower extremities, hypalgesia and thermohypesthesia of the left side of the trunk, and hypopallesthesia in the right lower extremity. ...

Human enteroviruses infect a large number of people every year. The great majority of infections are asymptomatic or cause only mild respiratory illness (common cold). However, these viruses may cause various clinically distinct diseases including aseptic meningitis (1). In the summer of 2006, there was an outbreak of aseptic meningitis in a nursery school in Kobe City, Japan. The school is sit...

Enteroviruses cause a wide spectrum of clinical disease. In this study, we describe the case of a young man with orchitis and aseptic meningitis who was diagnosed with enterovirus infection. Using unbiased "metagenomic" massively parallel sequencing, we assembled a near-complete viral genome, the first use of this method for full-genome viral sequencing from cerebrospinal fluid. We found that t...