Abstract Introduction Pharmacy teams, particularly in community pharmacy, are beginning to be recognised as important contributors mental health support and suicide prevention efforts. The need for appropriate referral triage routes from pharmacy other social care providers has been highlighted. (1) Support resources might provide a route triage, including third sector organisations. This will ...

K ATP channels were reconstituted in COSm6 cells by coexpression of the sulfonylurea receptor SUR1 and the inward rectifier potassium channel Kir6.2. The role of the two nucleotide binding folds of SUR1 in regulation of K ATP channel activity by nucleotides and diazoxide was investigated. Mutations in the linker region and the Walker B motif (Walker, J.E., M.J. Saraste, M.J. Runswick, and N.J. ...

those fields. Both of these techniques, however, require more observations than are practical for most field manEstimation of mean water status in a field is crucial to effective agers. Efforts have been made to characterize fields irrigation water management. Problems encountered with the estimation of mean field soil water status may be attributed to spatial variabilfrom fewer observations. T...

Drawing largely on Aidoo’s (1970) play, Anowa, as well as lived experiences, I argue on the philosophical flaws of Ashcroft’s (2009) claim that there is no inherent link between language and culture. This essay subsequently explores the implication of my argument on some transformational domains of English in particular though it has obvious applicability to the role of colonial languages in ge...

Study queStion What is the prevalence of different types of potentially hazardous prescribing in general practice in the United Kingdom, and what is the variation between practices? MethodS A cross sectional study included all adult patients potentially at risk of a prescribing or monitoring error defined by a combination of diagnoses and prescriptions in 526 general practices contributing to t...

Background Chimeric antigen receptor (CAR)-T cells represent a potentially curative strategy for B cell malignancies. A first successful clinical experience has been reported in systemic lupus erythematosus, suggesting that CD19-targeted CAR-T transfer was feasible and tolerable [1]. Objectives Since sclerosis (SSc) SLE are both severe diseases sharing implication their pathogenesis, we aimed a...

We show that a microscopic generalization of the Stokes–Einstein relation between the diffusion and shear viscosity coefficients, previously tested in simple liquids near melting, has a much wider range of application. The practical validity of the approach is accurately checked by performing extensive computer simulations in liquid sodium at temperatures ranging from 403 K to 1003 K. Transport...

In developing suitable numerical techniques for computational aero-acoustics, the DispersionRelation-Preserving (DRP) scheme by Tam and coworkers, and the optimized prefactored compact (OPC) scheme by Ashcroft and Zhang have shown desirable properties of reducing both dissipative and dispersive errors. These schemes, originally based on the finite difference, attempt to optimize the coefficient...

U.S. policymakers proclaim their commitment to Internet freedom while simultaneously endorsing restrictions on Internet exchange. Unfortunately, the tools – legal and technical – built to block copyright infringement, counterfeit sales, online gambling, or indecency, often find use to censor lawful expression here and abroad. In particular, the United States and its entertainment industries hav...

The evidence that points to the involvements of aminergic neurons in epilepsy can be divided into two sets. First, the work that indicates that drugs acting on amine metabolism can modify seizures, including data on the use of reserpine to lower brain amine concentrations in animals (Schlessinger et al., 1968) and man (Pallister, 1959), and p-chlorophenylalanine to decrease brain 5-hydroxytrypt...