The association of 5',8-cyclo-2'-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanos...

Biclustering is a commonly used type of analysis for realvalued data sets, and several algorithms have been proposed for finding different types of biclusters. However, no systematic approach has been proposed for exhaustive enumerating all (nearly) constant value biclusters in such data sets, which is the problem addressed in this paper. Using a monotonic range measure to capture the coherence...

body mass index (bmi) has been demonstrated to be associated with serum uric acid (sua) level in many developed countries, however, there is still a lack of large sample study in jiangsu province, one of the most economically developed regions in china, where fat-rich diet is common.through retrospective analysis in healthy subjects, we determined the association of bmi with hyperuricemia risk....

arthralgia is a common presenting symptom of many rheumatic diseases. vitamin d deficiency may lead to progression of skeletal symptoms to definite disease in susceptible subjects. this study was conducted to determine the relationship between vitamin d deficiency and unexplained arthralgia. patients with arthralgia not related to a definite clinical condition were selected prospectively among ...

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The inhibition of prothrombinase by tissue factor pathway inhibitor (TFPI) has been studied in the presence and absence of prothrombin. The rate constant of association of prothrombinase with full-length TFPI was 2.1x10(7) M-1.s-1 and 0.05x10(7) M-1.s-1 for the reaction with C-terminus truncated TFPI (TFPI1-161). The rate constant of dissociation was 0.65x10(-4) s-1 in both cases. The rate cons...