OBJECTIVES Few nationwide population-based studies have examined the burden of asthma during pregnancy. Here, we investigated the burden and medical treatment of asthma during pregnancy requiring healthcare utilisation in South Korea. DESIGN Cohort study. SETTING Nationwide insurance claims database. PARTICIPANTS A total of 1,306,281 pregnant women who delivered in South Korea in 2009-201...

It is known that the prevalence of gastroesophage-al reflux disease (GERD) in asthmatic patients is high. Although an endoscopic diagnosis of GERD based on the established Los Angeles (LA) classification requires the detection of erosive mucosal breaks, there are patients with GERD who have prominent erythema of the esophageal membrane without erosive mucosal breaks. Non-erosive mucosal change ...

Asthma is a multifactorial disease in which many factors play a role in its development and exacerbations. Viral infections are known to be the main cause of asthmatic exacerbations and are often the first manifestation of asthma in preschool age. However, there is much evidence suggesting a role of viral infections even in asthma development. Respiratory Syncytial Virus (RSV). has been first a...

We have measured the competitive antagonistic effect of chlorpheniramine in bronchi of 8 normal and 12 asthmatic subjects. Classical pharmacological theory states that the degree of competitive antagonism depends only upon 1) antagonist concentration at the receptor, and 2) receptor affinity. Delivery and affinity also influence agonist responsiveness, but measurement of bronchial antagoni...

In asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. If this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. In order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalat...

INTRODUCTION  Changes in the respiratory system of asthmatics are also due to the mechanical disadvantage caused by the increased airway resistance. OBJECTIVE  The study aims to evaluate the respiratory muscle strength and nutritional status of asthmatic children. METHOD  This is a prospective descriptive and transversal study with 50 children aged 7 to 12 years, who were placed into 2 grou...

chronic  obstructive  pulmonary  disease (copd)  and  asthma  are  major  public  health problems, which seems to have close association with psychiatric disorders. the present study was conducted to compare the psychological status between asthmatic and copd patients and clarify the relationship with severity of pulmonary obstruction. this cross-sectional study was planned to compare the psych...

Do bronchodilators adversely affect the prognosis of bronchial hyperresponsiveness? The possible adverse effects of bronchodilators on the prognosis of bronchial hyperresponsiveness (BHR) is currently a topical subject. Studies on this subject are, however, scarce. Many studies have dealt with the immediate or short term effect of bronchodilators on BHR, but to study the effects of these drugs ...

obesity as a common health risk is increasing all over the world. the aim of this study was evaluation of standing and sitting positions on spirometric values in obese asthmatic patients, in comparison with normal obese subjects. the study included 49 obese asthmatic patients with mean age of 42.63 years and body mass index of 36.06 kg/m 2 , and 51 control obese normal subjects with mean age of...