I diopathic pulmonary fibrosis (IPF) is a chronic devastating disease affecting 50 to 300 individuals per million with a median survival time of ,3 yrs [1]. The recent publication of evidence-based guidelines for the diagnosis and management of patients with IPF did not provide patients and care givers with any reason for optimism [2]. The only recommended procedures in this document were: long...

Humans have the greatest capacity for foresight but the least inclination to use it. Although 35% of Americans say that they or someone close to them have had a stroke, only 1% worry about it. The statistics resulted from a telephone survey of 1000 adults representative of the US demographics conducted by the American Heart Association.1 Moreover, only a minority know what to do to prevent a st...

This work is part of a larger framework where the goal is a high level language to write automaton based applications. The language lets the user specify the data structures to use and designate where the application must be optimized in space or in time. In a second step, we want the language to choose automatically which structure ts best to a given algorithm. This article deals with the foun...

Despite the increasing botnet threat, research in the area of botmaster traceback is limited. The four main obstacles are 1) the low-traffic nature of the bot-to-botmaster link; 2) chains of “stepping stones;” 3) the use of encryption along these chains; and 4) mixing with traffic from other bots. Most existing traceback approaches can address one or two of these issues, but no single approach ...

HEP Cluster is designed and implemented in Scientific Linux Cern 5.5 to grant High Energy Physics researchers one place where they can go to undertake a particular task or to provide a parallel processing architecture in which CPU resources are shared across a network and all machines function as one large supercomputer. It gives physicists a facility to access computers and data, transparently...

This paper describes an approach to VLSI design synthesis using both knowledge-based expert systems and data and control flow analysis. We are concerned with design synthesis as it proceeds from an algorithmic description of a VLSI system to a list of technology-independent registers, operators, data paths, and control signals. This paper discusses the development of the Design Automation Assis...

In a continuation of work on gene-enzyme relationships in histidine biosynthesis (1, 2) we have examined the early steps of the biosynthetic pathway in Salmonella typhimurium. It has been found that the first enzyme of the pathway catalyzes the condensation of 5-phosphoribosyl-1-pyrophosphate and adenosine triphosphate to form pyrophosphate and a product which has been isolated and characterize...

While reasoners are year after year scaling up in the classical, time invariant domain of ontological knowledge, reasoning upon rapidly changing information has been neglected or forgotten. On the contrary, processing of data streams has been largely investigated and specialized Stream Database Management Systems exist. In this paper, by coupling reasoners with powerful, reactive, throughput-ef...