Limited options are available for clozapine-resistant schizophrenia and intolerable side effects of clozapine. We conducted a systematic review of randomized-controlled trials (RCTs) to determine the efficacy and safety of aripiprazole augmentation of clozapine for schizophrenia. Electronic databases searched included PubMed, Scopus, Cochrane Central Register of Controlled Trials, Cumulative In...

BACKGROUND To analyze the relationship of cocoa intake to central and peripheral blood pressure, arterial stiffness, and carotid intima-media thickness in subjects with some cardiovascular risk factor. FINDINGS DESIGN A cross-sectional study of 351 subjects (mean age 54.76 years, 62.4% males). MEASUREMENTS Intake of cocoa and other foods using a food frequency questionnaire, central and ...

Epidemiological data suggest that insulin may have direct effects on large-vessel function, but thus far insulin has only been shown, after prolonged infusions, to slowly decrease peripheral vascular resistance by increasing muscle blood flow. We determined whether physiological doses of insulin affect function of large arteries, before any changes in peripheral blood flow, in vivo using pulse ...

BACKGROUND Although "squatting" in patients with tetralogy of Fallot is famous, the hemodynamic mechanism of the phenomenon has not been fully elucidated. To clarify the mechanism of squatting, the change in aortic pulsatile property induced by squatting was investigated. METHODS Twelve healthy young adults were enrolled in this study. The change in central pressure waveform induced by squatt...

UNLABELLED Antioxidants can decrease oxidative stress and combined with acute exercise they may lead to further decreases in blood pressure. The purpose of this study was to investigate the effects of 2 weeks of antioxidant supplementation on vascular distensibility and cardiovascular hemodynamics during postexercise hypotension. METHODS Twenty young subjects were randomized to placebo (n = 1...