OBJECTIVE To determine the extent of celiac autoimmunity in type 1 diabetic patients and the overlap between islet and celiac autoimmunity in their nondiabetic relatives. RESEARCH DESIGN AND METHODS IgA antibodies to tissue transglutaminase were determined in serum taken from 433 type 1 diabetic patients and 1,442 nondiabetic first-degree relatives. Samples with transglutaminase antibodies ab...

B-chronic lymphocytic leukemia (B-CLL) patients have a high prevalence of autoimmune phenomena, mainly autoimmune hemolytic anemia (AIHA). Immunoregulatory cytokines play a role in the regulation of both autoimmunity and leukemic B-cell growth. Mitogen-stimulated direct antiglobulin test (MS-DAT) is a recently described test able to disclose latent anti-RBC autoimmunity in AIHA. We investigated...

type i diabetes mellitus (dm) is frequently associated with autoimmune thyroid disease (atd). association of atd and type i dm has been described with varying frequencies but there is still debate about the situation in the iranian population. we investigated the prevalence of anti thyroid peroxidase (anti-tpo) antibodies and atd in children and adolescents with type i dm. a total of 145 patien...

systemic lupus erythematosus (sle) is a chronic autoimmune disease which results in damage to various organs. some animal studies have revealed that activation of toll-like receptors (tlrs) is important in the pathogenesis of sle. in the present study, the percentage of different immune cell subsets in 35 sle patients and 38 control subjects was analyzed by flow cytometry. we also assessed the ...

apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. it is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal dna fragmentation. although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

objective(s): multiple sclerosis (ms) is a serious neurological autoimmune disease, it commonly affects young adults. vitamin e (vit e) is an important component of human diet with antioxidant activity, which protects the body’s biological systems. in order to assess the effect of vit e treatment on this autoimmune disease, we established experimental autoimmune encephalomyelitis (eae), the ani...

Education has been described as and considered a remedy or treatment for the insecurity experienced by many young people today. To recognize mental health problems to seek is subject of today’s research, analyses academic debates on education. In this article, however, we will analyze, clarify discuss how medicalized metaphors contribute both an understanding reinforcing what call “autoimmune r...

DNA methylation plays an essential role in maintaining cellular function, and changes in methylation patterns may contribute to the development of autoimmunity, aging and cancer. Evidence for a role in autoimmunity comes from studies demonstrating that inhibiting T lymphocyte DNA methylation causes autoreactivity in vitro and a lupus-like disease in vivo. The autoimmunity is due in part to the ...

Type 1 diabetes is generally considered to be a chronic, immune-mediated disease with a subclinical prodrome during which beta cell autoimmunity becomes overt disease at a variable rate in genetically susceptible individuals. Accumulated evidence supports a critical role of environmental factors in its development. Prospective birth cohort studies show that the first signs of beta cell autoimmu...

A dangerously mutagenic protein is targeted to a single genomic site by ssDNA, report Ronai et al. (page 181). High frequency mutation at the immunoglobulin V region improves antibody affinity and specificity as part of the adaptive immune response. AID (activation-induced cytidine deaminase), which converts deoxycytidines to deoxyuridines, initiates this mutation process. These conversions the...