Post-mastectomy reconstruction is performed using implant-based or autologous techniques. Many women refuse or are poor candidates for implant-based reconstruction. We previously described a single-stage autologous technique that was most applicable in obese women with significant ptosis that made use of the mastectomy skin flap and subcutaneous tissue to reconstruct a breast mound. Here, we ex...

Restoration of soft tissue defects relies on proper structural support and bioactive components to instruct remodeling processes that have tightly controlled spatial temporal activity not yet fully understood. One clinical mainstay for reconstruction, autologous fat grafting, has widespread use in reconstructive esthetic surgeries owing the success liposuction techniques 1980s standardization a...

Lipomodeling is the process of relocating autologous fat to change the shape, volume, consistency, and profile of tissues, with the aim of reconstructing, rejuvenating, and regenerating body features. There have been several important advancements in lipomodeling procedures during the last thirty years. Four clinical steps are important for the success of engraftment: fat harvesting, fat proces...

In the area of cosmetic dermatology, some physicians have been injecting activated platelet-rich plasma into the face to promote cosmesis or using it to enhance fat grafts. However, subtle changes to the federal drug code (21 CFR 1271.1) made in 2004, when applied to activated PRP, purport to make this autologous substance a federally regulated drug requiring an extensive and costly Biologics L...

Facial asymmetry is a challenge for craniofacial surgeons to correct. Our center currently uses three dimensional (3-D) surgical designs by combining cone-beam computed tomography scans and 3-D photographs (3dMD, Atlanta, Ga). Computer assisted surgical designs can help the surgeon achieve facial skeletal symmetry [1]. However, even if skeletal symmetrisation can be achieved, such patients almo...

BACKGROUND The increased resorption and the difficulty of the fat graft take following autologous fat transplantation procedure are associated with reduced fat tissue revascularization and increased apoptosis of adipose cells. We suppose that the lipofilling procedure induces an inflammatory environment within the fat graft mass, whose evolution influences the efficacy of autologous fat graft s...