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Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease consisting of chronic phase (CP), accelerated phase (AP) and blast crisis (BC). In recent years, molecular mechanism of CMLBC has been comprehensively investigated. Based on the DNA sequencing, several somatic gene mutations in patients with CML-BC has been revealed. These gene including RUNX1, ASXL1, IKZF1, WT1, TET2, IDH1, ...
بیشتر افراد کنه های خانواده ی اریوفیده از آفات مهم گیاهان هستند. از سویی، تعدادی از آنها به دلیل تک خواری و سایر ویژگی های زیستی و بوم شناختی دارای پتانسیل به کارگیری در کنترل زیستی علف های هرز هستند. به منظور شناسایی کنه های خانواده ی اریوفیده فعال روی علف های هرز بوم نظام های کشاورزی در فصول زراعی سال های 1389 و 1390 ضمن بازدید از مناطق مختلف استان خراسان رضوی اقدام به نمونه برداری از گونه ها...
Introduction: Iran's plateau, especially in different regions of Iran, is composed of different climates, while in its southern areas summer temperatures reach 50 degrees above zero, the Caspian Mediterranean region is running wet weather. One of the most important indicators of climate difference is the issue of water. Today, water supply is one of the most important concerns to realize the go...
There is compelling evidence for association of rs1344706, an intronic SNP within the zinc-finger protein 804A gene (ZNF804A), with schizophrenia (SZ) and bipolar disorder (BD) (O'Donovan et al., 2008; Williams et al., 2011; Zhang et al., 2012). Recently, some of the potential molecular mechanisms underlying the association between rs1344706 and disease risk were published (Girgenti et al., 201...
Background and Objective: The importance of β-adrenergic signals in bone formation and resorption has been well investigated. However, little is known about the role of β -adrenergic signals in osteoblastic differentiation of mesenchymal stem cells (MSCs), which is critically important in bone physiology and pharmacology. In this study, RUNX2 and Osteocalcin gene expression were quantified in M...
1292 INTRODUCTION Since the recognition of acquired immune deficiency syndrome (AIDS), animal models have been developed to study various aspects of human immunodeficiency virus (HIV) infection, pathogenesis and control. The most common route of HIV transmission, sexual transmission (UNAIDS, 2012), has been investigated by simian immunodeficiency virus (SIV) infection of macaques and HIV infect...
بندپایان با داشتن بیش از یک میلیون گونه، بزرگترین شاخه جانوری محسوب می شوند. خانواده کنه های سخت در زیر راسته متااستیگماتا و راسته کنه سانان (آکارینا) از شاخه بندپایان قرار دارند (wall and shearer, 2001). تاکنون 650 گونه و در حدود 13 جنس در 5 زیرخانواده از آنها گزارش گردیده است (wall and shearer, 2001 ). به طوری که 10 درصد کنه ها از حیوانات اهلی تغذیه می کنند و در انتقال عوامل بیماری زا به انسا...
Introduction: Uncivil behaviors of clients including verbal attacks, irrational demands, and questioning employee competence can negatively affect service employees and may subsequently lead to job burnout and emotional exhaustion. Thus in this study, we explored the effect of client incivility on the work related conditions among nurses. Methods: This is an applied, descriptive-analytical stud...
Epilepsy affects approximately 1% of children under the age of 15, making it a very common neurological disorder in the pediatric population (Russ et al., 2012). In addition, ~0.4-0.8% of all pregnant women have some form of epilepsy (Hauser et al., 1996a,b; Borthen et al., 2009; Krishnamurthy, 2012). Despite the potential deleterious effects of antiepileptic drugs (AEDs) on the developing brai...
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Chroscinski et al., 2015) that described how we intended to replicate selected experiments from the paper "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors "(Willingham et al., 2012). Here we report the results of those experiments. We fou...
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