Behçet's disease (BD), also known as the Silk Road disease, is a multisystemic and rare inflammatory disorder primarily prevalent in populations along the Mediterranean Sea. Today, BD is defined as a crossroad between autoimmune and auto-inflammatory syndromes. Variety of syndromes including mucocutaneous manifestations such as oral and genital ulcers, papulopustular lesions and erythema nodosu...

background: it has been arguedthat unprecedented degree of human leukocyte antigen (hla) loci polymorphism within a population is requiredto avoid the devastating effects of infectious diseases. the present study was conducted to determine the associations between some of hla classi genes and the outcome of hepatitis b virus (hbv) infection.   methods: using sequential sampling method, 64 indiv...

Background: It has been arguedthat unprecedented degree of human leukocyte antigen (HLA) loci polymorphism within a population is requiredto avoid the devastating effects of infectious diseases. The present study was conducted to determine the associations between some of HLA classI genes and the outcome of hepatitis B virus (HBV) infection. Methods: Using sequential sampling method, 64 individ...

Behçet’s disease (BD) is a multi-systemic vasculitis characterized by triad made up of oral aphthosis, genital aphthosis and uveitis which may or not be associated with visceral involvement. Other times described in the ancient silk road, BD increasingly found countries south Sahara mixing populations. Our objective was to describe epidemiology clinical characteristics an African country. Metho...

Background: Behcet's disease (BD) is a chronic multisystem vasculitis with an unknown etiology. During the past years, several reports are published on occult hepatitis B infection (OBI), presence of virus (HBV) DNA in absence HBsAg, rheumatic diseases. Objectives: The current study aimed to, firstly, investigate prevalence OBI patients BD, and, secondly, its potential association clinical and ...

Background: The Human Leukocyte Antigen (HLA) is the most polymorphic region in human genome. Moreover, HLA haplotype frequencies are largely used in transplantation, the treatment of autoimmune diseases, and population-based studies. The present study aimed to determine HLA-A, -B, -DR alleles and haplotype frequencies in 88 unrelated donors of Iranian Gilak ethnic group, by Polymerase Chain Re...

AIMS/BACKGROUND To identify an HLA association with pseudoexfoliation of the lens capsule to support the hypothesis that there is a genetic predisposition to pseudoexfoliation. A randomised trial would be ideal for establishing a relation but is more costly and time consuming to conduct. Case-control studies provide an alternative method of establishing a relation. METHODS The study group com...