Treatment of hospital acquired urinary tract infections (UTIs) caused by extended-spectrum betalactamases producing Klebsiella pneumonae is a major problem. This organism expresses a high level of resistance to many groups of antibiotics. Fosfomycin is an agent which is recommended for treatment of UTIs caused by ESBLs producers. The aim of this study is to determine the sensitivity pattern of ...

OBJECTIVES Enterobacteriaceae with extended-spectrum beta-lactamases (ESBLs) are now widespread and simple phenotypic tests are required to detect them in diagnostic laboratories. We investigated the performance of screening methods at 16 hospitals in South-East England. METHODS Sixteen laboratories in South-East England submitted 1195 consecutive Enterobacteriaceae isolates found to be resis...

Klebsiella pneumoniae remains a major pathogen responsible for localized infections such as cystitis and pneumonia, and disseminated infections that may result in severe sepsis and death. Invasive disease such as liver abscesses and endogenous endophthalmitis are associated with capsular serotypes K1 and K2. These infections require a prolonged course of antimicrobial treatment which has evolve...

BACKGROUND & OBJECTIVES Pseudomonas aeruginosa possessing chromosomally inducible blaPDCalong with other intrinsic mechanism causes infection with high mortality rate. It is difficult to detect inducible AmpC enzymes in this organism and is usually overlooked by routine testing that may lead to therapeutic failure. Therefore, three different inducers were evaluated in the present study to asses...

that hospital outbreaks of ESBL-producing E. coli may occur6. The reason why ESBL-producing K. pneumoniae is more likely to cause clusters of infection than E. coli has not been fully explored. While scores of scientists study bacterial pathogenesis, attention must surely be placed by the scientific community on the reasons why some strains are more “hospital-adapted” than others. Ability to at...

conclusions our data showed that, the high prevalence of beta-lactamase genes among isolates, and it. our findings may provide useful insights in replace of the appropriate antibiotics and it may also prevents of esbls, mediated resistance problem. results from 145 strains of e. coli, 51(35.2%) and 61(42.1%) isolates were resistance to ceftazidime and cefotaxime, respectively. esbl production w...

Abstract Background Ceftibuten (CTB) is an oral cephalosporin active against Enterobacterales approved by the US Food and Drug Administration in 1995. Avibactam (AVI) a potent inhibitor of extended-spectrum β-lactamases (ESBLs), serine carbapenemases AmpC that can be administered orally. We evaluated vitro activity CTB-AVI molecularly characterized produced most common (BLs) assessed AVI concen...

Abstract Background Epidemiological data of cephalosporin-resistant Enterobacterales in Sub-Saharan Africa is still restricted, and particular Mozambique. The aim this study was to detect characterize extended-spectrum ?-lactamase (ESBL) - plasmid-mediated AmpC (pAmpC)-producing clinical strains Escherichia coli at Maputo Central Hospital (MCH), a 1000-bed reference hospital Maputo, Methods A t...