introduction: primary small cell carcinoma of theesophagus (pscec) associated with paraneoplastic sweating syndrome is a rare disease characterized with rapid growth rate, metastasis at the time of diagnosis, and poor prognosis. the lung is the most common site for small cell carcinoma but this malignancy includes 0.1% to 1% of all gastrointestinal and 0.8% to 2.7% of esophageal malignancies. s...

following failure of systemic chemotherapy, transarterial chemoembolization (tace) is an available method to control unresectable liver metastases from colorectal carcinoma (crc). the aim of present study was to evaluate the efficacy of chemoembolization for inoperable metastatic liver lesions from crc. forty-five crc patients with liver metastases resistant to systemic chemotherapy were enroll...

squamous cell carcinoma (scc) is the most common malignancy of the oral cavity. this study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.the authors searched all electronic databases (medline, embase and cochrane) for all the articles published from 1970 to janua...

background and aims : adverse drug reactions (adrs) are one of the major leading causes of death in the world. this study was designed and conducted because of the importance of adverse events in the cancer treatment setting and regarding this issue there is no study exploring adverse reactions of acute hematologic malignancy chemotherapy in iranian population. methods : this was a prospective,...

background: recent advances in cancer treatment have resulted in an increased number of cancer survivors. fertility might be impaired by cancer itself or through gonadal damage as a consequence of radio-chemotherapy. damages to reproductive organs are seen in minimally upto 30% of cancer patients. the aim of the present study was evaluate the attitude of iranian oncologists toward fertility pre...

background: thioredoxin reductase 1 (txnrd1) and thioredoxin interacting protein (txnip) also known as thioredoxin binding protein 2 or vitamin d3-upregulated protein 1 are key players in oxidative stress control. thioredoxin (trx) is one of the major components of the thiol reducing system and plays multiple roles in cellular processes. computational analyses of txnrd1, txnip and trx expressio...

objective: the goal of this study is to evaluate the efficacy of intraperitoneal (jp) cisplatin as consolidation treatment, in epithelial ovarian cancer patients with pathologically negative surgical reassessment, following first-line platinum-based chemotherapy. methods: this study included 22 patients with figo stage (iic- iv) epithelial ovarian cancer (eoc) which had no evidence of disease a...

background: nephrotoxicity is one of the major side-effects of cisplatin that has been seen in about 20% of treated patients. the aim of this study was to assess the effectiveness of a forced hydration protocol comprised of isotonic saline, potassium chloride (kcl) and magnesium sulfate (mgso4) on prevention of cisplatin nephrotoxicity. methods: this cross sectional prospective study was perfor...

background: cancer is the third leading cause of death in iran. novel chemotherapeutic agents can lead to considerable improvements in cancer treatment, although using these agents requires special skills and experiences. the aim of this study was to evaluate the impact of a short course education on nurses’ knowledge and attitude. methods: overall, 24 nurses participated in this short educatio...

ginger, the rhizome of zingiber officinalis, has long been used as herbal medicine for its antiemetic effect. for evaluating the effect of zingiber officinalis on nausea and vomiting (n and v) in patients receiving cisplatin based regimens, a randomized double-blind placebo-controlled cross-over clinical trial was carried out in patients receiving cisplatin in combination with other chemotherap...