Background: Cerebrovascular reactivity has been identified as an important contributor to secondary injury following moderate severe traumatic brain (TBI). “Gold-standard” intracranial pressure (ICP) based indies of cerebrovascular are limited by their invasive nature poor spatial resolution. Near infrared spectroscopy (NIRS) indices minimally and have improved In this study, classical machine-...

A novel approach for estimation variance based sensitivity indices for models with dependent variables is presented. Both the first order and total sensitivity indices are derived as generalizations of Sobol’ sensitivity indices. Formulas and Monte Carlo numerical estimates similar to Sobol’ formulas are derived. A copula based approach is proposed for sampling from arbitrary multivariate proba...