The fabrication of drug nanoparticles (NPs) with process-mediated tunable properties and performances continues to grow rapidly during the last decades. This study investigates the synthesis and phase tuning of nanoparticulate itraconazole (ITR) mesophases using quasi nanoemulsion precipitation from acetone/water systems to seek out an alternative pathway to the nucleation-based NP formation. I...

Nanoemulsion is one the most attractive drug delivery for researchers to treat fungal diseases and getting interested in increasing solubility of low soluble drugs. The objective this research was develop a topical nanoemulsion formulation Posaconazole with intention enhance its aqueous local action. By employing High Pressure Homogenization (HPH) method, oil water formulated 0.2% cinnamon as l...

Baicalin is one of the main bioactive flavone glucuronides derived as a medicinal herb from the dried roots of Scutellaria baicalensis Georgi, and it is widely used for the treatment of fever, inflammation, and other conditions. Due to baicalin's poor solubility in water, its absolute bioavailability after oral administration is only 2.2%. The objective of this study was to develop a novel baic...

The aim of the present study was determine optimum processing conditions and nanoemulsion formulation for preparation gingerol shogaol from ginger extract-based subcritical water. For this purpose, nanoemulsions were prepared with rotor-stator homogenizer varied surfactant cosurfactant concentrations (24%, 26% 28% v/v), stirring speed (22,000 rpm, 24,000 rpm). time is adjusted to 30 minutes. de...

Indomethacin, a potent nonsteroidal anti-inflammatory drug, has been used in the treatment of various kinds of pains, inflammation and arthritis. However, oral administration of indomethacin produces serious gastrointestinal adverse effects. Therefore the aim of the present investigation was to evaluate the anti-inflammatory effects, skin irritation, activation energy and histopathology of indo...