OBJECTIVE To evaluate the association between migraine and cognitive decline among women. DESIGN Prospective cohort study. SETTING Women's Health Study, United States. PARTICIPANTS 6349 women aged 65 or older enrolled in the Women's Health Study who provided information about migraine status at baseline and participated in cognitive testing during follow-up. Participants were classified i...

Background: As yet migraine has been established as one of the risk factors for ischemic stroke. Some of the factors have been assessed for the explanation of this relation. Hyperhomocysteinemia is seen partly both in stroke and in migraine. This study was conducted to determine the mean plasma levels of homocysteine in ischemic stroke patients on the basis of migraine history.Methods: This cro...

The relationship between migraine and psychopathology has been discussed far more often than it has been systematically studied. Twentieth-century investigators have frequently described the obsessional rigid, angry personality postulated to characterize migraine sufferers. More recent population-based studies have demonstrated associations between migraine and depression and migraine and panic...

Cutaneous allodynia is a common feature accompanying migraine attacks and considered a clinical marker for central sensitization. In a longitudinal study, we wanted to investigate if allodynia in migraine patients is a predictor of increasing frequency of migraine days. We included 3029 well-defined, web-based migraine patients (86% female, mean age 42.8 ± 11.4 years, 61% migraine without aura)...

BACKGROUND AND PURPOSE Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population. METHODS This was a case-...

Migraine is the most common form of headache disorder globally. The etiology of migraine is multifactorial, with genetic components and environmental interactions considered to be the main causal factors. Some researchers postulate that deficits in mitochondrial energy reserves can cause migraine or an increase in homocysteine levels can lead to migraine attacks; therefore, vitamins could play ...

BACKGROUND AND PURPOSE Few and conflicting data exist on the case fatality rate in stroke patients with basilar artery dolichoectasia. We analyzed basilar artery characteristics (diameter, height of bifurcation, transverse position) and 5-year mortality (all-cause, nonstroke vascular, and stroke) in patients with brain infarction. METHODS The basilar artery diameter was measured with a 16-dio...

Background and objectives: Migraine is the seventh most common cause of disability among all ailments according to the World Health Organization. Despite the availability of some medicines for prevention of migraine, their complications are a cause for concern. Traditional system of medicine and use of medicinal herbs can be beneficial in management of migraine. “Gol-e-ghan...

Objectives: There are some comorbidity between migraine, tension headaches, and some psychological  factors including Early Maladaptive Schemas (EMSs). This research aimed to identify the EMSs  associated with migraine and tension headaches.  Methods:  The present study was of cross sectional and correlational studies. The measures included  Headache Disability Invento...

Background Intravenous infusion of adenylate cyclase-activating polypeptide-38 (PACAP38) provokes migraine-like attacks in 65-70% of migraine sufferers. Whether aggregation of migraine in first-degree relatives contributes to this discrepancy in PACAP38-induced response is unknown. We hypothesized that genetic enrichment plays a role in triggering of migraine and that migraine without aura pati...