Interest in the biology of brown adipose tissue (BAT) has moved from the field of cold adaptation and cellular bioenergetics to the field of nutrition and obesity in recent years. This is mainly due to studies on BAT of ‘cafeteria-fed’ or obese rodents (Rothwell & Stock, 1979; Himms-Hagen, 1985; Trayhurn, 1986). In fact most studies on BAT have been focused on direct or indirect assay of the un...

Metaheuristic algorithm such as BAT algorithm is becoming a popular method in solving many hard optimization problems. This paper investigates the use of Bat algorithm in combination with Back-propagation neural network (BPNN) algorithm to solve the local minima problem in gradient descent trajectory and to increase the convergence rate. The performance of the proposed Bat based Back-Propagatio...

A discrete bat algorithm (DBA) is proposed for optimal permutation flow shop scheduling problem (PFSP). Firstly, the discrete bat algorithm is constructed based on the idea of basic bat algorithm, which divide whole scheduling problem into many subscheduling problems and then NEH heuristic be introduced to solve subscheduling problem. Secondly, some subsequences are operated with certain probab...

Bats harbor many viruses, which are periodically transmitted to humans resulting in outbreaks of disease (e.g., Ebola, SARS-CoV). Recently, influenza virus-like sequences were identified in bats; however, the viruses could not be cultured. This discovery aroused great interest in understanding the evolutionary history and pandemic potential of bat-influenza. Using synthetic genomics, we were un...

2 adrenergic receptor ( 2-AR) agonists have been used as antihypertensive agents, in the management of drug withdrawal, and as sedative analgesics. Since 2-AR agonists also influence the regulation of body temperature, we explored their potential as antipyretic agents. This study delineates the central neural substrate for the inhibition of rat brown adipose tissue (BAT) and shivering thermogen...

Brown adipose tissue (BAT) is responsible for cold- and diet-induced thermogenesis, and thereby contributes to the control of whole-body energy expenditure (EE) and body fat content. BAT activity can be assessed by fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) in human subjects. Grains of paradise (GP, Aframomum melegueta), a species of the ginger family, contain pungent, aroma...

OBJECTIVE Brown adipose tissue (BAT) is present in adult humans where it may be important in the prevention of obesity, although the main factors regulating its abundance are not well established. BAT demonstrates seasonal variation relating to ambient temperature and photoperiod in mammals. The objective of our study was therefore to determine whether seasonal variation in BAT activity in huma...

Bats are beneficial to ecosystems around the world, and are often keystone species. However, bat populations are declining worldwide and conservation efforts are needed to conserve bat species throughout the world. Worldwide, superstitions and fear of bats prevail and prolong negative attitudes and human hostility toward most bat species. In the case of other species (e.g. wolves and alligators...

We applied digital gene expression profiling to determine the transcriptome of brown and white adipose tissues (BAT and WAT, respectively) during cold exposure. Male C57BL/6J mice were exposed to cold for 2 or 4 days. A notable induction of genes related to glucose uptake, glycolysis, glycogen metabolism, and the pentose phosphate pathway was observed in BAT from cold-exposed animals. In additi...

Brown adipose tissue (BAT) is vital for proper thermogenesis during cold exposure in rodents, but until recently its presence in adult humans and its contribution to human metabolism were thought to be minimal or insignificant. Recent studies using PET with 18F-fluorodeoxyglucose (18FDG) have shown the presence of BAT in adult humans. However, whether BAT contributes to cold-induced nonshiverin...