نتایج جستجو برای: benzimidazole resistance
تعداد نتایج: 378063 فیلتر نتایج به سال:
Herein, we report a bulky variant of bis-benzimidazole carboxylate ligand. The five-position the benzimidazole groups were substituted with tertiary butyl intention preventing bis-ligation and oligomerization, as was observed in other studies using similar ligands. Unfortunately, even bulkier substituents, new ligand still formed bis-ligated structure. Although did not afford desired mono-ligat...
Introduction: Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention radical-scavenging capacity many natural synthetic supplements drugs has been extensively evaluated. Material methods: In present study, seven N,N'-disubstituted benzimidazole-2-thiones with ester (1 - 4) hydrazide (5 7) s...
β-tubulins are structural components of microtubules and the targets of benzimidazole fungicides used to control many diseases of agricultural importance. Intron polymorphisms in the intron-rich genes of these proteins have been used in phylogeographic investigations of phytopathogenic fungi. In this work, we sequenced 2764 nucleotides of the β-tubulin gene (Pp tubB) in samples of Phakopsora pa...
The benzimidazole D-ribonucleosides TCRB and BDCRB are potent and selective inhibitors of human cytomegalovirus (HCMV) replication. Two HCMV strains resistant to these compounds were selected and had resistance mutations in genes UL89 and UL56. Proteins encoded by these two genes are the two subunits of the HCMV "terminase" and are necessary for cleavage and packaging of viral genomic DNA, a pr...
The RNA-dependent RNA polymerase of hepatitis C virus (HCV) is the catalytic subunit of the viral RNA amplification machinery and is an appealing target for the development of new therapeutic agents against HCV infection. Nonnucleoside inhibitors based on a benzimidazole scaffold have been recently reported. Compounds of this class are efficient inhibitors of HCV RNA replication in cell culture...
Four bipolar molecules, named 1-, 2-, 3-, and 4-3cbzBIZ, composed of tricarbazole (3cbz) substituted benzimidazole, were synthesized characterized.
Anthelmintic resistance in parasitic nematodes of livestock is a chronic problem in many parts of the world. Benzimidazoles are effective, broad-spectrum anthelmintics that bind to and selectively depolymerise microtubules. Resistance to the benzimidazoles, however, developed quickly and is caused by genetic changes in genes encoding beta-tubulins, subunits of microtubules. In Haemonchus contor...
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