background: vegetation (food stuff) is grown in soil that contains many radioactive elements such as 238u (uranium), 232th (thorium) and 40k (potassium), which may get deposited either due to radioactive fallout or/and by absorption from the soil and can pose serious health hazards. materials and methods: natural radioactivity, radiological hazards and annual effective dose assessment was carri...

The potential photoaffinity reagents 2,5-diazido-3-methyl6-isopropyl-l,4-benzoquinone (DAZMIB) and 2,5-diazido-3,6dimethyl-l,4-benzoquinone (DAZDMQ), which are analogs of the well-known inhibitor 2,5-dibromo-3-methyl-6-isopropyl1,4-benzoquinone (DBMIB), block photosynthetic electron transport in spinach chloroplasts. On irradiation, at relatively high concentrations, DAZMlB inhibits electron fl...

To investigate the protein-ubiquinone interaction in the bovine heart mitochondrial succinate-cytochrome c reductase region of the respiratory chain, three fluorine substituted ubiquinone derivatives, 2,3-dimethoxy-6-(9'-fluorodecyl)-1,4-benzoquinone (9FQ), 2-methoxy-5-trifluoromethyl-6-decyl-1,4-benzoquinone (TFQ), and 2-methoxy-5-trifluoromethyl-6-(9'-fluorodecyl)-1,4-benzoquinone (9FTFQ), we...

Gas-phase product detection studies of o-hydroxyphenyl radical and O2 are reported at 373, 500, and 600 K, at 4 Torr (533.3 Pa), using VUV time-resolved synchrotron photoionisation mass spectrometry. The dominant products are assigned as o-benzoquinone (C6H4O2, m/z 108) and cyclopentadienone (C5H4O, m/z 80). It is concluded that cyclopentadienone forms as a secondary product from prompt decompo...

The hemodynamic and proinflammatory effects of endothelin-1 (ET-1) in proximal (1st/2nd order) and terminal (3rd/4th order) arterioles and venules were examined in small intestine submucosa of anesthetized guinea pigs. Vessel diameter (D), red blood cell velocity, and blood flow (Q) were determined in eight proximal and eight terminal microvessels before and at 20 min of ET-1 suffusion (10(-10)...

A new concept for the structural design of valence tautomeric (VT) metal complexes involving the formation of stable adducts of a tetracoordinate transition metal complex with a suitable bidentate redox-active ligand has been computationally studied using the DFT B3LYP*/6-311++G(d,p) method. The calculations, performed on a series of adducts of Co(II) diketonates with o-benzoquinone and its mon...

BACKGROUND With 600 million people using betel quid (BQ) globally, and smokeless tobacco (SLT) use being more wide-spread; the duo is an uphill public health concern in South Asian countries. SLT and/or BQ use increases the risk for morbidity and mortality from oral cancer. Because SLT and/or BQ use is initiated during adolescence, it renders this group more vulnerable; and particular attention...

We examined the Csalóka Spring, which has the highest radon concentration in the Sopron Mountains (West Hungary) (, yearly average of 227 ± 10 Bq L(-1)). The main rock types here are gneiss and micaschist, formed from metamorphism of former granitic and clastic sedimentary rocks respectively. The aim of the study was to find a likely source of the high radon concentration in water. During two p...

Endothelin-1 (ET-1) has been proposed to contribute to the regulation of vascular tone in humans. BQ-123, an ET(A) receptor antagonist, has also been reported to increase forearm blood flow (FBF) in vivo; however, the efficacy of BQ-123 as an antagonist of ET-1 has not been evaluated in the forearm. The present study investigated the effects of BQ-123 on changes in FBF in response to ET-1 and n...

UNLABELLED Endothelin-1 (ET-1) plays a major role in the pathophysiology of hypertension and its associated cardiovascular risk. We tested the hypothesis that chronic nebivolol treatment reduces ET-1-mediated vasoconstrictor tone in adult humans with elevated blood pressure (BP). Furthermore, reducing ET-1 vasoconstrictor activity contributes to the improvement in endothelial vasodilator functi...