Irinotecan (Camptosar) is an active chemotherapeutic agent for lung, gastric, esophageal, and colorectal cancers and a potent radiosensitizer. This phase I study was designed to assess the maximum tolerated dose of weekly irinotecan combined with concurrent radiotherapy for patients with locally advanced, unresectable gastric, gastroesophageal junction, or esophageal cancer. Patients who receiv...

Raltegravir is a potent human immunodeficiency virus 1 (HIV-1) integrase strand transfer inhibitor that is being developed as a novel anti-AIDS drug. The absorption, metabolism, and excretion of raltegravir were studied in healthy volunteers after a single oral dose of 200 mg (200 microCi) of [(14)C]raltegravir. Plasma, urine, and fecal samples were collected at specified intervals up to 240 h ...

background & aim: eucalyptus l'her. [an aromatic genera of the family (myrtaceae)] is native to australia and other tropical species is planted worldwide. the purpose of this study is to extract and identify the essential oils components of four species of eucalyptus l'her. cultivated in botanical garden of kashan, central iran. experimental: leaves of e. largiflorens, e. intertexta, ...

We use a cosmological numerical simulation to study the tidal features produced by a minor merger with an elliptical galaxy. We find that the simulated tidal features are quantitatively similar to the red tidal features, i.e., dry tidal features, recently found in deep images of elliptical galaxies at intermediate redshifts. The minor merger in our simulation does not trigger star formation due...

In this paper the efficiency of the method of Least Squares Harmonic Estimation (LS-HE) for detecting the main tidal frequencies is investigated. Using this method, the tidal spectrum of the sea level data is evaluated at two tidal stations: Bandar Abbas in south of Iran and Workington on the eastern coast of the UK. The amplitudes of the tidal constituents at these two tidal stations are not t...

Based on the conventional sequential-accretion paradigm, we have proposed that, during the migration of first-born gas giants outside the orbits of planetary embryos, super Earth planets will form inside the 2:1 resonance location by sweeping of mean motion resonances (Zhou et al. 2005). In this paper, we study the subsequent evolution of a super Earth (m1) under the effects of tidal dissipatio...

Hierarchical clinoptilolite and L zeolites are prepared using optimized tandem dealumination-desilication treatments. The main challenge in the post-synthetic modification of these zeolites is the high Al content, requiring a tailored dealumination prior to the desilication step. For natural clinoptilolite sequential acid treatments using aqueous HCl solutions were applied, while for L a contro...

A two-dimensional west coast tidal model, built on the ADCIRC platform (an unstructured grid two-dimensional depth-integrated shallow water model), has been developed to examine the scope for reliable and fully predictable electricity generation from UK coastal waters using an ambitious combination of estuary barrages, tidal lagoons and tidal stream generator arrays. The main emphasis has been ...

Tidal current asymmetry, an important factor for waterborne substance transport, is strongly affected by the changing shoreline. Lingding Bay (LDB), located in center of Guangdong-Hong Kong-Macao Greater Area, has suffered great shoreline changes since 1970s. A well-validated numerical model built to investigate how impacts tidal which quantified skewness parameter. Two types asymmetries, flow ...

INTRODUCTION Atelectasis and distal airway closure are common clinical entities of general anaesthesia. These two phenomena are expected to reduce the ventilation of dependent lung regions and represent major causes of arterial oxygenation impairment in anaesthetic conditions. In the present study, the behavior of the elastance of the respiratory system (Ers), as well as the lung aeration asses...