The safety of using otic formulations is often of concern for practitioners and pet owners alike, with "safe" in this context meaning no adrenocortical suppression. This study evaluated the effect of four glucocorticoid-containing otic formulations on plasma cortisol concentrations, measured by corticotropin stimulation testing (plasma cortisol concentrations before and after corticotropin inje...

Clobetasone butyrate, a new corticosteroid with a high topical activity, has been compared with prednisolone phosphate and a placebo in the treatment of inflammation following cataract extraction. These 2 steroids were more effective in relieving postoperative inflammation than placebo (P less than 0.05), though no obvious clinical differences between the 2 compounds emerged from this investiga...

Background: Acute radiation dermatitis is a very common side effect of radiation therapy in large numbers of cancers including breast cancer. Despite high prevalence rate of acute radiation dermatitis and also wet desquamation, a few trials on prophylaxis of this complication using topical treatment have been conducted. Despite effectiveness of topical corticosteroids in treatment of acute radi...

BACKGROUND Dexamethasone added to local anesthetic for brachial plexus block improves postoperative pain after arthroscopic rotator cuff repair, as compared with the use of local anesthetic alone. Dexamethasone is present in non-particulate form in local anesthetic solution, while betamethasone is partially present in particulate form. The particulate betamethasone gradually decays and is expec...

A four month old male infant born with a birth weight of 2.5 kg presented with chickenpox. On examination, he weighed 11 kg and had cushingoid features. His blood pressure was normal and had multiple papulovesicular lesions characteristic of chickenpox. The child had to be treated with oral acyclovir in view of cushingoid features. At fifteen days of life, a private practitioner had prescribed ...

Indian Journal of Pharmaceutical Sciences 551 September October 2009 Accepted 10 September 2009 Revised 11 June 2009 Received 05 September 2008 Indian J. Pharm. Sci., 2009, 71 (5): 547-551 min, respectively and decrease in 2% organic phase, the retention time for butenaÞ ne hydrochloride and betamethasone were observed to be 5.8 and 8.2 min, respectively. The solution stability study revealed t...

the photocatalytic degradation of betamethasone sodium phosphate was investigated in aqueoussuspensions of zinc oxide nanoparticular with diameter size 20 nm under a variety of conditions.different parameters such as irradiation time, the amount catalyst (0.12-0.8 g lh), initialconcentration of drug (10-50 mgljand initial ph values (ranging from 3 to ii) were investigatedin the presence of vari...

We have experienced two cases (Case 1: 21-year-old female, Case 2: 26-year-old female) of systemic lupus erythematosus (SLE) associated with hyperthyroidism. Case 1 had been treated with methimazole (MMI) and betamethasone for approximately two years. Although thyroid function improved with the treatment, laboratory data of SLE deteriorated. She was successfully treated with betamethasone alone...

CLINICAL CASES Several treatments have been described for the management of patients with herpes zoster ophthalmicus (HZO). However, the progress of these patients is usually slow, and many of them develop postherpetic neuritis (PHN). In the present paper, three clinical cases are presented, in which a significant symptomatic improvement was obtained by using a preauricular injection of a mixtu...

In the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in Parkinsonian rats was studied using the microdialysis technique. Our results showed significant differences (p