Pseudomonas aeruginosa (P. aeruginosa) infection is one of the major causes keratitis. However, effective prophylactic and therapeutic vaccines against P. keratitis have yet to be developed. In this study, we explored use membrane vesicles (MVs) as a vaccine well immune sera derived from MV-immunized animals treatment for corneal infections in C57BL/6 mice. mice were intramuscularly immunized w...

purpose: to report a case of cloverleaf skull syndrome with cleft palate. results: we report a 20-day-old boy with cloverleaf-shaped skull deformity, very constricted cranium and prominent temporal bones associated with severe proptosis, maked lid retraction, conjunctival chemosis, exposure keratitis, corneal opacity and cleft palate. ct-scan dislosed fusion of the coronal, sagittal and lambdoi...

Contact lens wearers are at great risk of developing microbial keratitis because of incorrect usages and unhygienic maintenance of contact lenses. Therefore, the present study was planned to provide data that will be helpful in selecting the anti-microbial to cure microbial keratitis. One hundred bacterial isolates from conjunctiva of contact lenses wearer were isolated, identified and subjecte...

BACKGROUND Corneal ulcers are one of the most common eye problems in the horse and can cause varying degrees of visual impairment. Secondary infection and protease activity causing melting of the corneal stroma are always concerns in patients with corneal ulcers. Corneal collagen cross-linking (CXL), induced by illumination of the corneal stroma with ultraviolet light (UVA) after instillation o...

Infectious keratitis after penetrating keratoplasty (PK) is a devastating condition that may result in graft failure and poor visual outcome. In this study, we retrospectively reviewed the medical records of patients who underwent PK between 2009 and 2014, and recorded those who developed infectious keratitis. We compared the predisposing factors and organisms isolated to those identified in ou...

Eye trauma and contact lens wear are the main factors that predispose to the development of infectious keratitis. The existing therapies fail to control the inflammation-driven tissue damage that occurs during Pseudomonas aeruginosa infection. Antibiotic treatment reduces bacterial burdens, but better interventions are needed to alleviate tissue damage resulting from local inflammation. We have...

We report the case of a patient diagnosed with Avellino corneal dystrophy (ACD) who developed diffuse interstitial keratitis following excimer laser insitu keratomileusis (LASIK). ACD is an autosomal dominant corneal dystrophy characterized by multiple asymmetric stromal opacities that impair vision. Accepted treatments for this condition include corneal transplantation and phototherapeutic ker...