aptamers define a new interesting class of receptor molecules with capability of binding to potentially any kind of molecules of interest. structurally, they are composed of nucleic acids (rna, dna or a mixture of both) with high specificity and affinity to amino acids, drugs, proteins and other molecules. apatmers are isolated from complex libraries of synthetic nucleic acids against the desir...

b ackground: toxoplasmosis is a serious disease in immunocompromised patients and pregnant women. differentiation of acute and chronic infection is a major challenge in serodiagnosis of the disease. since the aim of this study was to assess the diagnostic utility of recombinant sag1 (rec- sag1) for the detection of toxoplasma -specific igm antibodies in human sera, by an enzyme-linked immunosor...

background and aims: celery mosaic virus (cemv) is one of the causal agents of viral diseases in celery (apium graveolens). cemv is a member of the potyvirus genus in potyviridae family. the virus is naturally transmitted by aphids in a non-persistent manner. during growing season 2006-2007 viral disease symptoms were observed in celery fields grown in tehran province (bage daneshkade, mohamads...

In recent decades natural biological products (including components of animals and plants) have increasingly been investigated to discover new drugs. In this study, different dendrotoxins from Eastern green mamba (Dendroaspis aungusticeps) venom were examined for their effects on neurotransmitter release in chicken biventer cervices nerve-muscle preparation using twitch tension recording techni...

Linear and whorled nevoid hypermelanosis (LWNH) is characterized by hyperpigmentation following Blaschko’s line which usually occurs in infancy or early childhood. Affected individuals have no accompanying extracutaneous manifestations. Recently, a postzygotic mutation (p.Asp110Gly) the KITLG gene was identified on hyperpigmented skin of patient with LWNH. KIT-ligand (KITLG), also known as stem...

Nanoparticles offer great promise for more effective drug delivery. However, their particulate nature typically results in rapid systemic clearance by immune cells blood. Currently, to understand these interactions, nanoparticle association is probed ex vivo with whole While assays give important information about the relative cell association, they do not consider changes homeostasis or comple...

Nucleic acid-based biosensors for the detection of specific proteins combine typical programmability synthetic DNA systems with artificially controlled DNA-protein communication. The high-affinity interaction between a target protein and ligand, such as an aptamer sequence, or double stranded domain, small peptide, is paired nature-mimicking molecular mechanism allowing probing, processing, tra...