Tetrodotoxin (TTX)-binding proteins are present in toxic TTX-bearing animals, such as pufferfish and gastropods. These may prevent autotoxicity. However, TTX-binding also found the nontoxic marine shore crab, Hemigrapsus sanguineus. Here, we isolated protein, HSTBP (Hemigrapsus sanguineus protein), from hemolymph of H. elucidated its primary structure using cDNA cloning. HSTBP, a 400 kDa acidic...