For the quantification of sedative and anesthetic drug midazolam its main (active) metabolites 1-hydroxymidazolam, 4-hydroxymidazolam 1-hydroxymidazolam glucuronide in human serum, EDTA plasma, heparin plasma urine a single accurate method by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) has been developed. Protein precipitation as sample preparation, witho...

Benzoylpaeoniflorin (BP) is a potential therapeutic agent against oxidative stress related Alzheimer's disease. In this study, a more rapid, selective, and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to determine BP in rat plasma distinguishing with a monoterpene isomer, benzoylalbiflorin (BA). The method showed a linear response from 1 to 1000 ng/m...