Reconstructive surgery of complex three-dimensional defects of the midface/maxilla following treatment of advanced squmous cell carcinoma of the maxilla is challenging. Primary or secondary reconstruction using autogenous bone grafts or alloplastic materials are standard procedures, however such procedures may be associated with complications. In particular secondary reconstructions often requi...

Autologous bone or inert alloplastic materials used in cranial reconstructions are techniques that are associated with resorption, infection, and implant exposure. As an alternative, a calcium phosphate-based implant was developed and previously shown to potentially stimulate bone growth. We here uncover evidence of induced bone formation in 2 patients. Histological examination 9 months postope...

xv CHAPTER I: INTRODUCTION 1.1 Background and Problem Statement 1 1.2 Objectives of the Research 4 1.3 Project Overview 5 CHAPTER II: LITERATURE REVIEW 2.

Critical size bone defects due to trauma or disease are very difficult to repair via the natural growth of the host bone. Therefore, these defects must be filled with a bridging material (scaffold), which should also, in combination with relevant cells and signalling molecules, promote the regeneration of new bone tissue. In this context, bone regeneration is one of the most attractive areas in...

Natural spinal tissues have unique dynamic properties and it is crucial to investigate the full response of implants related biomedical materials ensure compatibility with host tissue. Silicon nitride a promising bioceramic for implants. In this study, mechanical silicon were comprehensively evaluated using novel efficient testing methods, at both material structural level. The correlation betw...