The metabolic adaptations to fasting in the liver are largely controlled by the nuclear hormone receptor peroxisome proliferator-activated receptor alpha (PPARα), where PPARα upregulates genes encoding the biochemical pathway for β-oxidation of fatty acids and ketogenesis. As part of an effort to identify and characterize nutritionally regulated genes that play physiological roles in the adapta...

Piperaquine (PQ) is an antimalarial drug whose high lipid solubility suggests that its absorption can be increased by a high-fat meal. We examined the pharmacokinetics of PQ phosphate (500 mg given orally) in the fasting state and after a high-fat meal in eight healthy Caucasian volunteers (randomized crossover). Plasma PQ concentration-time profiles were analyzed by using noncompartmental phar...

Polycystic ovary syndrome is define as illness in women that a reproductive age because commonendocrinopathy and lead to dysfunction also infertility. PCOS usually alignment withinsulin resistance metabolic syndrome, it think the outcome of genetic effect additionto ecological factor. In this study (100) samples which divided into 40 heath 60samples with PCOS. It diagnosed by ovarian morphology...

OBJECTIVE To observe the physiological and biochemical effects of intermittent fasting combined with hunger-resistant food on mice, and to evaluate the safety and beneficial effects of this regimen. METHODS One hundred and forty-four adult ICR mice were divided into 4 groups: standard feed AL group (ad libitum intake of standard feed), hunger-resistant food AL group (ad libitum intake of hung...

Autophagy is regulated by nutrient and energy status and plays an adaptive role during nutrient deprivation and ischemic stress. Metabolic syndrome (MetS) is a hypernutritive state characterized by obesity, dyslipidemia, elevated fasting blood glucose levels, and insulin resistance. It has also been associated with impaired autophagic flux and larger-sized infarcts. We hypothesized that diet-in...

BACKGROUND Chronic kidney disease is an emerging problem in the majority Muslim countries. Despite the uncertainties of the risks involved, some Muslim patients undergoing chronic haemodialysis choose to observe intermittent fasting during the month of Ramadan. This study aims to investigate the effect of Ramadan fasting in haemodialysis patients residing in a tropical climate country. METHOD...

To the Editor: Accurate assessment of bone resorption may be of significant value for selecting women for antiresorptive therapy, monitoring of therapeutic response in treated individuals, and predicting fracture risk (1 ). This goal may be facilitated by measurement of biochemical markers of bone metabolism. The Serum CrossLaps One Step ELISA measures fragments derived from the C-terminal telo...

Background & Aim of the Study: Increased levels many biomarkers, including liver enzymes, blood urea and serum creatinine as well glycemic markers have been reported following coronavirus (COVID-19) infection, leading to development acute disease. This study aims measure follow-up biomarkers (fasting glucose, urea, creatinine, total bilirubin, enzymes AST, ALT, ALP) in otherwise healthy par...

Our earlier work demonstrated that the rate of protein synthesis in the exocrine cells of the rat pancreas is constant in different physiological states, including prolonged fasting. In this study we have followed the fate of the protein in the pancreatic cells of the fasting animal in vivo as well as in vitro. The data were obtained by quantitative radioautography and by biochemical determinat...

Introduction: Obese individuals have elevated levels of inflammatory and cell adhesion molecules that can critically induce the occurrence of atherosclerosis. Aerobic exercise training reduces biochemical markers and anthropometric characteristics involved in atherosclerosis. However, little is known about the effect of resistance exercise training on these biomarkers. This study aimed to inves...