The effect of ultrasound on the degradation of polymers and the release rate of incorporated molecules within those polymers was examined. Up to 5-fold reversible increases in degradation rate and up to 20-fold reversible increases in release rate of incorporated molecules were observed with biodegradable polyanhydrides, polyglycolides, and polylactides. Up to 10-fold reversible increases in re...

Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto.fi Author Laura Elomaa Name of the doctoral dissertation Synthesis of biodegradable photocrosslinkable polymers for stereolithography-based 3D fabrication of tissue engineering scaffolds and hydrogels Publisher School of Chemical Technology Unit Department of Biotechnology and Chemical Technology Series Aalto University publication seri...

Design of mechanical skeletons of biodegradable synthetic polymers such as poly(L-lactic acid) (PLLA), poly(DL-lactic-co-glycolic acid) (PLGA), and poly(ε-caprolactone) (PCL) is important in the construction of the hybrid scaffolds of biodegradable synthetic polymers and naturally derived polymers such as collagen. In this study, cylinder-shaped PLLA, PLGA, and PCL sponges were prepared by the ...

Tissue-adhesive materials are emerging biomaterials with potential applications in wound healing patches, tissue sealants, and haemostat materials. Tissue adhesives based on synthetic polymers generally have good adhesion but not biodegradable. However, the long-term presence of non-biodegradable body can cause secondary harm to patient. An ideal adhesive should meet following requirements: adh...

in the past decades, environmental pollution caused by plastic packing materials, restrictions of petroleum resources and their high price attracted many researchers to produce biodegradable packaging materials. poor mechanic properties and high water vapor permeability are two main defects of biodegradable polymers. nanotechnology is a modification method in this case. in the current study, th...

This review deals with the targeting of drugs to the lower gastrointestinal tract i.e. colon. Colonic drug delivery becomes important for localized action as well as for improved systemic availability of peptide and proteins. Drugs which have absorption window in the colonic region have been targeted using different novel technologies. pH sensitive polymers and prodrug based formulation have be...

A large number of different polymers have been developed and studied for application as DNA carriers for non-viral gene delivery, but the DNA binding properties are not understood. This study describes the efficiency of nanoparticle formation by time-resolved fluorescence measurements for poly(β-amino esters), cationic biodegradable polymers with DNA complexation and transfection capability. Fr...

A method of introducing intrinsically photo luminescent properties to biodegradable polymer is introduced, exemplified by the synthesis of intrinsically photoluminescent polylactones that enable non-invasive monitoring and tracking of material degradation in vivo in realtime, as well as the formation of theranostic nanoparticles for cancer imaging and drug delivery.