BACKGROUND Rapid dose assessment using biological dosimetry methods is essential to increase the chance of survival of exposed individuals in radiation accidents. OBJECTIVES We compared the expression levels of the FDXR and RAD51 genes at 6 and 18 MV beam energies in human peripheral blood lymphocytes. The results of our study can be used to analyze radiation energy in biological dosimetry. ...

The biological tissue has been mimicked and replaced by other materials, which have shown certain radiological similarity determined by attenuation coefficient (μ), density and atomic number. Specifically, in molecular imaging and radiation therapy have been developed multifunctional radiopharmaceuticals which contain beta/gamma and/or light emitters to chronic degenerative diseases treatment. ...

Background: Lymphocyte-dicentric assay is the most generally accepted method for biological dosimetry of overexposed individuals. In this study, the frequency of unstable chromosome aberration in blood lymphocytes was used to estimate radiation dose received by individuals. Evaluation of dose using a calibration curve produced elsewhere may have a significant uncertainty therefore, experiments ...

TG-69 is a task group report of the AAPM on the use of radiographic film for dosimetry. Radiographic films have been used for radiation dosimetry since the discovery of x-rays and have become an integral part of dose verification for both routine quality assurance and for complex treatments such as soft wedges (dynamic and virtual), intensity modulated radiation therapy (IMRT), image guided rad...

Thoracic cancer treatment presents dosimetric difficulties due to respiratory motion and lung inhomogeneity. Monte Carlo and deformable image registration techniques have been proposed to be used in four-dimensional (4D) dose calculations to overcome the difficulties. This study validates the 4D Monte Carlo dosimetry with measurement, compares 4D dosimetry of different tumor sizes and tumor mot...

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A new concept in the therapy of both neoplastic and non-neoplastic diseases is discussed in this article. Photodynamic therapy (PDT) involves light activation, in the presence of molecular oxygen, of certain dyes that are taken up by the target tissue. These dyes are termed photosensitizers. The mechanism of interaction of the photosensitizers and light is discussed, along with the effects prod...

This study compares the EPID dosimetry algorithms of two commercial systems for pretreatment QA, and analyzes dosimetric measurements made with each system alongside the results obtained with a standard diode array. 126 IMRT fields are examined with both EPID dosimetry systems (EPIDose by Sun Nuclear Corporation, Melbourne FL, and Portal Dosimetry by Varian Medical Systems, Palo Alto CA) and th...

Abstract This review describes the basic principles of radiometal-theranostics and its dawn based on development positron-emitting 86 Y Y-labeled radiopharmaceuticals to quantify biodistribution dosimetry 90 analogue therapeutics. The nuclear inorganic (including cross section data, irradiation, radiochemical separation recovery) led preclinical clinical evaluation citrate EDTMP complexes yield...