In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds purified, characterised and tested on different cell lines bacterial strains. From family, 7-(2,4-dinitrophenoxy)-5-hydroxy-3-phenyl-4H-chromen-4-one (C3) was shown be extremely active strains methicillin-resistant Staphylococcus aureus, Pseudomonas aerugin...

Pirfenidone, an oral anti-fibrotic and anti-inflammatory medication used for the treatment of idiopathic pulmonary fibrosis (IPF), has been proposed to treat post-COVID pneumonia (PF). However, pirfenidone displays side effects which include hepatotoxicity anorexia. Cubane cyclooctatetraene (COT) derivatives were prepared as bioisostere/biomotif replacements phenyl ring explore potential change...