Assessing the lethality of 'early,' potentially organ-confined prostate cancer (PCa) is one of the central controversies in modern-day urological clinical practice. Such cases are often considered for radical 'curative' treatment, although active surveillance may be equally appropriate for many men. Moreover, the balance between judicious intervention and overtreatment can be difficult to judge...

Tumour markers are substances that are produced either by the tumour itself or by the body in response to the presence of cancer or certain benign conditions that can aid in the diagnosis of cancer. The subject of tumour markers is a broad one, and there is an abundance of data. A literature review of potential molecular markers relevant to oral neoplasia was undertaken in terms of a perspectiv...

Channa punctatus is a freshwater fish belonging to family Ophiocephalidae. This fish is available in almost all over the country. In present communication molecular study of COI region of mitochondrial gene was done to find out intraspecific differences in genome of Channa punctatus habitating in different states of India having variable environmental conditions. Result showed minor variations ...

Finding a new species is a rare event in easy-to-see and well-studied organisms like butterflies, especially if they inhabit well-explored areas such as the Western Palaearctic. However, even in this region, gaps in taxonomic knowledge still exist and here we report such a discovery. Using a combined analysis of chromosomal and molecular markers we demonstrate that Polyommatus blue populations ...

With insights gained through molecular profiling, cancer is recognized as a heterogeneous disease with distinct subtypes and outcomes that can be predicted by a limited number of biomarkers. Statistical methods such as supervised classification and machine learning identify distinguishing features associated with disease subtype but are not necessarily clear or interpretable on a biological lev...

Hormone assays are being developed in the laboratory to detect specific molecular markers in nonclinical populations. Epidemiology is increasingly using these assays to improve the precision with which disease processes and exposures can be defined. This growing body of molecular epidemiology requires a high degree of cooperation between the assay developer and the assay user. We draw on our ex...

Guest Editorial Immunohistochemistry in principle is no different from other techniques in molecular biology, an experimental approach for which the quality of the results rely entirely on the analyte, reagents, precise experimental technique, correct application of controls and, ultimately, accurate interpretation of the data based on all of the aforementioned factors. Despite this statement b...

There is an enormous unmet need for biological markers to characterize disease type, status, progression, and response to therapy. We are developing and applying an integrated bioanalytical platform and clinical research program to facilitate comprehensive differential phenotyping of patient samples and enable the discovery of biomarkers. The platform employs high-throughput, quantitative analy...