Thanks to containing tumor-related molecules, small extracellular vesicles (sEVs) are emerging as biomarkers in tumor liquid biopsy and commonly employed diagnose a specific cancer. However, pan-cancer screening method for pre-symptomatic patients is crucial achieving the early cancer detection. Herein, lipid-protein capture system on herringbone (HB) microfluidic chip (HBEV-Chips) isolate mult...

this article reviews the recently published data on the diagnosis of cancer with proteomics, including the major proteomics technologies and promising strategies for biomarker discovery and development.  most of the tumor markers are proteins that either numerically increase in response to the alteration of cancer conditions or are produced by cancer cells. however, they are natural compounds o...

at present, when a clinical diagnosis of parkinson’s disease (pd) is made, serious damage has already been done to nerve cells of the substantia nigra pars compacta. the diagnosis of pd in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategies designed to slow or halt the progression of this disease that possibly prevents accumulation o...

in genomics, the ability to amplify rare transcripts has enabled rapid advances in the understanding of gene expression patterns in human disease. the inability to increase the copy number and to detect the signal of rare proteins as unique species in biological samples has hindered the ability of proteomics to dissect human disease with the same complexity as genomic analyses. advances in nano...

During the past decade, newborn screening (NBS) for cystic fibrosis (CF) has disseminated worldwide after endorsements by the Centers for Disease Control and Prevention and the CF Foundation. Similar to widespread introduction of other NBS programs, CF NBS implementation occurred on a region-by-region basis by using a wide variety of screening strategies and analytical methods. All strategies b...

In this paper, we present a proof of concept screening for monoclonal immunoglobulin as a leukemia tumor marker using a surface plasmon resonance (SPR) bio-sensing platform. This screening method is based on measurements of immunoglobulin levels in human serum and the determination of the relative concentrations of kappa and lambda light chains. The kappa/lambda ratio is used to determine the p...