Acknowledgements: This research was supported by National Institute of Mental Health Grants MH 52617 and MH 77908 to Lauren B. Alloy, and MH 52662 to Lyn Y. Abramson. Abstract Bipolar disorders and substance use disorders (SUDs) show high co-occurrence. One explanation for this co-occurrence may be common personality vulnerabilities involved in both. We tested whether high Behavioral Approach S...

BACKGROUND Childhood maltreatment (abuse and neglect) can have long-term deleterious consequences, including increased risk for medical and psychiatric illnesses, such as bipolar disorder in adulthood. Emerging evidence suggests that a history of childhood maltreatment is linked to the comorbidity between medical illnesses and mood disorders. However, existing studies on bipolar disorder have n...

There is an urgent need for biomarkers of bipolar disorder to optimize its treatment. Although inflammatory markers have been most established biomarkers of bipolar disorder, molecular basis of cytokine elevation is not known. We hypothesized that plasma mitochondrial DNA (mtDNA), one of mitochondrial damage-associated molecular patterns, would contribute to inflammation observed in bipolar dis...

BACKGROUND The long-term efficacy of psychological interventions for bipolar disorders has not been tested. AIMS This study assessed the efficacy of group psychoeducation to prevent recurrences and to reduce time spent ill for people with bipolar disorders. METHOD A randomised controlled trial with masked outcome assessment comparing group psychoeducation and non-structured group interventi...

Obsessive-compulsive disorder (OCD) often co-occurs with psychotic and bipolar disorders; this comorbidity complicates the clinical management of these conditions. In this population-based longitudinal and multigenerational family study, we examined the patterns of comorbidity, longitudinal risks, and shared familial risks between these disorders. Participants were individuals with a diagnosis ...