Drug-metabolizing enzymes found primarily in the liver (CYP450) are a major determinant of therapeutic drug response. Polymorphism dependent upon race/ethnic origin for CYP2D6 is now well-established. Despite consistent reports of ethnic differences in pharmacologic response to antidepressants and neuroleptics, there is a paucity of data on controlled clinical trials and studies determining pol...

We report on a 46-year-old black man who resided in Alabama with normal transferrin saturation, mild hyperferritinemia, chronic hepatitis C, and 3+ iron in hepatocytes and Kupffer cells. Exome sequencing revealed heterozygosity for SLC40A1 D270V (exon 7, c.809A→T), a mutation previously reported only in 1 black patient with iron overload who resided in the Republic of South Africa. The present ...

The properties of the main measure of acculturative stress have not been systematically examined. The authors conducted a study of the construct validity of the Social, Attitudinal, Familial, and Environmental Acculturative Stress Scale (A. M. Padilla, Y. Wagatsuma, & K. J. Lindholm, 1985) in a sample of 248 African American university students (156 of whom attended a historically Black college...

INTRODUCTION Trypanosoma brucei rhodesiense typically causes acute and severe human African trypanosomiasis in Zambia and other countries in Eastern and Southern Africa. Although a few atypical cases of chronic and mild forms of this disease were reported in Zambia more than 40 years ago, no such cases have been diagnosed over the last four decades. CASE PRESENTATIONS For the first case, a 19...

INTRODUCTION Reported findings on the relationship between adiposity and atherosclerotic cardiovascular disease (ACVD) risk in rheumatoid arthritis (RA) are contradictory and originate in developed populations. Approximately 80% of ACVD now occurs in developing countries. We aimed to ascertain the associations of clinical obesity measures with metabolic cardiovascular risk and atherosclerosis i...

This article reports on a perception study that was carried out with Zulu-English bilinguals in order to investigate how suprasegmental aspects differ in Black South African English compared to White English-speaking South African English. Two prosodic phenomena were investigated: prosodic focus marking on noun phrases (NPs) and prosodic boundary marking. The results support existing claims in ...

Copyright: © 2013. The Authors. Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License. Background: In South Africa cervical cancer is the second most commonly occurring cancer amongst women, and black African women have the highest risk of developing this disease. Unfortunately, the majority of South African women do not adhere to recommended regular...

This bibliography identifies items of interest to those working with Alzheimer's disease in Black and African American communities. The list is not exhaustive and selection does not constitute endorsement. Additional information may be found in the general diversity bibliography. Theses Videos Books and Booklets 10 signs every African-American should know.

Black children are children from Africa, the Caribbean, and Latin America whose ancestry is partially or fully Black African. Children who are black have large and active melanosomes producing eumelanin and providing an intrinsic sun protection to the skin, yielding a Fitzpatrick Skin Type of IV–VI. The skin tone is accompanied by curled hair of lesser density and reduced oil distribution along...

BACKGROUND People from Black ethnic groups (African-Caribbean and Black African) are more prone to develop psychosis in Western countries. This excess might be explained by perceptions of disadvantage. AIMS To investigate whether the higher incidence of psychosis in Black people is mediated by perceptions of disadvantage. METHOD A population-based incidence and case-control study of first-e...