Introduction: Atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formation in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels. However, these drugs have certain adverse effects, which cause serious and sometimes fatal consequences. Methods: Plants essential oils were prepared and ...

Molted feather sampling is a useful tool for genetic analyses of endangered species, but it is often very laborious due to the low quality and quantity of the DNA obtained. In the present study we show the parts of feathers that resulted in better yield of DNA. In descending order these were: blood clot outside the umbilicus, umbilicus (without blood clot), tip, inner membrane, and small calamu...

close-up view of a clot forming in human blood shows beautifully how the different blood components are crammed into the plasma. (The scanning electron micrographs have been coloured to emphasize the different structures.) Red blood cells (red) are entangled with the fibrin (yellow) that makes up the scaffolding of the clot. The platelets (blue) — which initiate clotting — are fragments of larg...

※ Venous thromboembolism (VTE) consists of two related conditions caused by blood clots: deep vein thrombosis (DVT) and pulmonary embolism (PE). ※ DVT is a condition in which a blood clot develops in one of the deep veins, most commonly in the lower legs. If part of the clot breaks off, travels and becomes lodged in the blood vessels of the lungs, it will cause PE. ※ In healthy individuals, the...

Laser thrombolysis is under investigation as a safe and rapid therapy for arterial recanalization in acute embolic stroke. Clot formation is a complex process affected by many factors that lead to differences in strength and hemoglobin concentration in samples formed from whole blood. The strength of thrombus formed in vivo also varies with age. Laser thrombolysis experiments were performed usi...

Blood coagulation in vivo is a spatially nonuniform, multistage process: coagulation factors from plasma bind to tissue factor (TF)-expressing cells, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes of activated platelets. We studied spatial regulation of coagulation using two approaches: 1), an in vitro experimental model of clot formation in a...

Introduction Coagulation alterations after a subarachnoid hemorrhage (aSAH) secondary to aneurysm rupture are frequent and clinically relevant. They may impact negatively in the outcome. The diagnosis of coagulopathy with the standard tests is limited as only the initial part of coagulation process is being assessed. In contrast, thromboelastography provides the whole blood clot information, al...

Thrombus fragmentation during endovascular stroke treatment, such as mechanical thrombectomy, leads to downstream emboli, resulting in poor clinical outcomes. Clinical studies suggest that risk is dependent on clot composition. This current study presents the first experimental characterization of composition-dependent fracture properties blood clots, addition development a predictive model for...

The complement and coagulation systems closely interact with each other. These interactions are believed to contribute to the proinflammatory and prothrombotic environment involved in the development of thrombotic complications in many diseases. Complement MASP-1 (mannan-binding lectin-associated serine protease-1) activates coagulation factors and promotes clot formation. However, this was mai...

Despite the criticisms of substrate variability, the euglobulin lysis time remains a most useful assay of plasma plasminogen activator. It is simple to execute and correlates well with the radioactive clot assay (Sawyer, Fletcher, Alkjaersig, and Sherry, 1960), dilute blood clot lysis time (Fearnley, Balmforth, and Feamley, 1957), and fibrin plate method (Kekwick and Mackay, 1954). It continues...