the malignant process is uncertain. Blood group antigens provide a convenient system for the study of changes related to malignancy. The structure of the ABO and Rh blood group antigens is well studied. They are present in almost all body tis sues; highly specific antisera can be produced, and various specific tests for these antigens exist (1, 4, 6, 10). ABO and D (Rh0) blood group antigen dis...

The number of blood group systems, currently 35, has increased in the recent years as genetic variations defining red cell antigens continue to be discovered. At present, 44 genes and 1568 alleles have been defined as encoding antigens within the 35 blood group systems. This paper provides a brief overview of two genetic technologies: single nucleotide variant (SNV) mapping by DNA microarray an...

The purpose of this investigation was to delineate the presence of ABH blood group antigens on the surface of normal and leukemic lymphocytes and to determine whether this genetically directed and supposedly constant characteristic (1) is altered in the neoplastic cell. The study was an extension and synthesis of the following previously recorded observations. 1) The recent demonstration that r...

Types MM, NN, and MN blood group substances have been isolated. All three materials are glycoproteins containing about 24 % iV-acetyhreuraminic acid, 10 % galactosamine, 5% glucosamine, and 14% galactose. The hexosamines appear to be N-acetylated. Amino acid analysis of the glycoproteins reveals them to be similar in composition and to be especially rich in serine and threonine. Treatment of th...

found in secretions and body fluids, and exhibit size heterogeneity upon purification, as discussed above. Based on these observations, it is likely that many glycosyltransferases share a common domain structure with the sialyltransferase. What is the basis for the subcellular localization of the glycosyltransferases? It has been demonstrated that the fi-galactoside a2,6-sialyltransferase is lo...

The aim of the present study was to evaluate the expression of blood group antigens in squamous bronchial metaplasia in order to determine whether this factor could identify patients at risk of lung cancer. In total, 100 bronchial biopsies were included in the present study. The cases were classified according to the World Health Organization grading system. Immunohistochemical stains for histo...

S 193 raffinose were found to be the most potent. N agglutination and panagglutination after dialysis were found to be inseparable properties of the lectin, and the authors agree with an earlier suggestion that lectin agglutination may be dependent upon the metabolic selective carbohydrate-binding power of some plant proteins. One of the authors was allergic to the seed powder; precautions are ...