Abstract Introduction Complement activation is a key mechanism of Ischaemia reperfusion injury, with the alternative pathway driving damage in particular. The main regulator factor H. We hypothesised that homodimeric mini-factor H (HDM-FH; PMID:29588430) may protect transplanted kidneys from complement mediated when administered during normothermic perfusion machine perfusion. Methods Kidneys w...

(1) Background: Arrhythmia, which is an umbrella term for various types of abnormal rhythms heartbeat, has a high prevalence in both the general population and patients with coronary artery disease. So far, it remains unclear how different arrhythmia would affect myocardial perfusion risk/severity ischemia. (2) Methods: A computational model circulation coupled to global cardiovascular system w...

Acute and Short Term Hyperoxemia: How about Hemorheology and Tissue Perfusion? Tissue perfusion is a major factor determining the prognosis, morbidity and mortality in ICU patients. Perfusion may carry on via uninterrupted delivery of sufficient substrate and oxygen to the tissues. From this point of view, determinants of tissue perfusion that routinely mentioned are cardiac output, vascular to...

This study examined whether the calcium antagonist nisoldipine can shift the relations between sodium excretion, papillary blood flow, renal interstitial pressure, and renal perfusion pressure toward lower pressures in spontaneously hypertensive rats. Mean arterial pressure decreased similarly by 9% and 12% in Wistar-Kyoto and spontaneously hypertensive rats after nisoldipine (0.5 microgram/kg ...

This study examined whether the calcium antagonist nisoidipine can shift the relations between sodium excretion, papillary blood flow, renal interstitial pressure, and renal perfusion pressure toward lower pressures in spontaneously hypertensive rats. Mean arterial pressure decreased similarly by 9% and 12% in Wistar-Kyoto and spontaneously hypertensive rats after nisoidipine (0.5 /xg/kg bolus+...

BACKGROUND This research describes an early preclinical study of the biophysical mechanisms governing changes in myocardial T2 during vasodilation in normal myocardium. METHODS AND RESULTS Theoretical modeling and experimental studies in an instrumented pig model (n=7) provided measures of changes in myocardial T2, relative blood volume (BV), and microcirculation oxygen levels (%O2) during in...

OBJECTIVES To assess the value of CT perfusion imaging in the differentiation of different histological categorization of benign tumours from malignant tumours in patients with parotid neoplasms. METHODS CT perfusion was successfully performed in 62 patients with parotid neoplasms whose diagnoses were confirmed by surgery or biopsy. The software generated a tissue time-density curve (TDC) and...

Tumor growth and the incorporation of |'H]thymidine into tumor DNA in vivo are increased about 3 times in adult rats (greater than 250 g) after 1 to 2 days of starvation or the induction of diabetes with streptozotocin. These tumor growth responses require hyperlipemia and are reversed by refeeding or insulin treatment, respectively. They do not occur in young tumor-bearing rats (less than abou...

Myocardial mean myoglobin oxygen saturation was determined spectroscopically from isolated guinea pig hearts perfused with red blood cells during increasing hypoxia. These experiments were undertaken to compare intracellular myoglobin oxygen saturation in isolated hearts perfused with a modest concentration of red blood cells (5% hematocrit) with intracellular myoglobin saturation previously re...