Although the presynaptic protein α-synuclein is a recognized player in neurodegeneration, its precise physiologic function(s) and/or role in human disease remains unclear. An emerging consensus from previous studies in lower-order systems is that α-synuclein interferes with vesicle-trafficking pathways; however putative neuronal correlates are unknown. Here we explore consequences of α-synuclei...

This paper provides a synthesis and further development of a global modelling approach introduced in Pesaran, Schuermann and Weiner (2004), where country specific models in the form of VARX* structures are estimated relating a vector of domestic variables, xit, to their foreign counterparts, x*it, and then consistently combined to form a Global VAR (GVAR). It is shown that the VARX* models can ...

Radionuclide gated cardiac blood pool (GBP) imaging was used to quantitatively assess the severity of acute aortic valvular regurgitation produced experimentally in 10 anesthetized dogs. Right ventricular (RV) and left ventricular (LV) stroke counts (end-diastolic minus end-systolic counts in RV and LV regions of interest) were used as indices of the stroke volumes of the two ventricles. Regurg...

BACKGROUND Genotyping error can increase both type I and II errors. In order to elucidate potential genotyping errors, data quality control often includes testing genotype data for deviations from Hardy-Weinberg Equilibrium (HWE). METHODS The Hardy-Weinberg Disequilibrium (HWD) coefficient and the ability to reject the null hypothesis of HWE were calculated analytically for genotype data from...

As the model is a positive system (namely its state variables can never become negative if the system is initialized at generic non-negative conditions), the bifurcation from stable to unstable of the diseasefree equilibrium (DFE) X0 = [0, 0, 0, 0] T , i.e. a state of the system characterized by the absence of the parasite, can only occur via an exchange of stability. This implies that the DFE ...

The Medical Journal of Australia ISSN: 0025729X 3 May 2010 192 9 534-536 ©The Medical Journal of Australia 2010 www.mja.com.au Lessons from Practice and evisceration was immediately apparent. She was ta emergency department at a major regional centre, whe intubated and transferred to tertiary care. A laparotom 75% of the small bowel had prolapsed through a rectal p above the peritoneal reflecti...

The larval hemoglobins of the insect Chironomus fenfans, present in solution in hemolymph, were demonstrated to be exclusively monomeric with a molecular weight of approximately 15,900. This finding was based on studies of sedimentation velocity at various concentrations and with the use of agents generally effective in subunit separation, together with determinations by sedimentation equilibri...

Statistical tests that detect and measure deviation from the Hardy-Weinberg equilibrium (HWE) have been devised but are limited when testing for deviation at multiallelic DNA loci is attempted. Here we present the full Bayesian significance test (FBST) for the HWE. This test depends neither on asymptotic results nor on the number of possible alleles for the particular locus being evaluated. The...

Usual models of search markets describe the equilibrium pricing strategies of sellers confronted to a population of buyers searching for the best deal: in equilibrium, a seller perfectly anticipates both the pricing strategy of his rivals and the search behaviour of buyers, and optimally responds to it. We show in this paper that “less rational” sellers are not able to learn this Nash-equilibri...

In Saccharomyces cerevisiae, at least three proteins (IF(1), STF(1), and STF(2)) appear to be involved in the regulation of ATP synthase. Both IF(1) and STF(1) inhibit F(1), whereas the proposed function for STF(2) is to facilitate the binding of IF(1) and STF(1) to F(1). The oligomerization properties of yeast IF(1) and STF(1) have been investigated by sedimentation equilibrium analytical ultr...