Toltrazuril 5% suspension (Baycox, Bayer Canada, Ontario, Canada) was administered to six adult horses followed by blood collection and assay to determine the concentration of toltrazuril and its principal metabolites, toltrazuril sulfone and toltrazuril sulfoxide. From this data, the maximum concentration (C(max)), elimination half-life (T 1/2), and mean residence times of the plasma were dete...

ANALYSIS OF THE BIOACTIVITY, METABOLISM, AND PHARMACOKINETICS OF ANTHOCYANINS IN HUMANS Colin Kay Advisors: University of Guelph, 2004 Professor B. J. Holub Professor G. Mazza Recent interest in the health-promoting properties of berry anthocyanins has been based on studies reporting their significant in vitro antioxidant activities. However, information regarding the bioavailability, metabolis...

Acute leukemia is a critical neoplasm of white blood cells. In order to differentiate between the metabolic alterations associated with two subtypes of acute leukemia, acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), we investigated the serum of ALL and AML patients and compared with two controls (healthy and aplastic anemia) using (1)H NMR (nuclear magnetic resonance) spect...

The effects of heparin, ethylenediaminetetraacetic acid (EDTA), sodium citrate and sodium fluoride/potassium oxalate on plasma biochemistry results in dogs were studied and compared with serum. Blood specimens from 10 apparently clinical healthy dogs were collected and placed in different tubes containing each anticoagulant tested. Differences in albumin, acetylcholinesterase, ionized calcium a...

Present review focuses on the possible role of tryptophan (Trp) – kynurenine (Kyn) pathway in mechanism(s) COVID-19 associated psychiatric complications. SARS-CoV-2 infection, that causes COVID-19, triggers overproduction interferon-gamma (IFNG), a pro-inflammatory cytokine. IFNG activates indoleamine 2,3-dioxygenase-1 (IDO), enzyme catalyzes Trp conversion into Kyn, and enzymes down-stream Kyn...

Introduction. Extracorporeal membrane oxygenation has found wide application in clinical practice during the COVID-19 pandemic. Oxidative stress, endothelial dysfunction, and systemic inflammatory response syndrome play an important role pathogenesis of COVID-19. Our research was designed to study correlations in-between those factors impact extracorporeal on them. Aim. The function patients wi...

Introduction In recent years, the quality of male semen has been decreasing, and number infertilities caused by asthenozoospermia is increasing year year, diagnosis treatment patients with are gradually receiving attention whole society. Due to unknown etiology complex pathogenesis, there no specific for asthenozoospermia. Our previous study found that administration chestnut polysaccharide cou...

In order to investigate the relationship between insulin to glucagon ratio and metabolic factors in transitional period of dairy cows, 28 cows heifers with body condition score of 3.25- 3.75 were selected. Dairy cows received close up diet, from 21 days prepartum until parturition and lactation diet according to nutritional requirements after parturition. Blood was sampled at 10 days before and...

Presently, three reversal strategies are available to reverse the anticoagulant activity of direct oral anticoagulants, each with various limitations or drawbacks. A new agent that addresses some these gaps in therapy is advanced clinical trials. Ciraparantag a small molecule specifically designed bind non-covalently by charge-charge interaction unfractionated heparin and low molecular weight h...

This study was carried out to evaluate the effect of onion extract on growth performance, carcass characteristics and some blood metabolites in Ross and Cobb broiler chickens. One hundred sixty, 1-d-old broiler chickens (mean initial weight: 36.5 ± 1 g) of male sex (Ross-308 and Cobb) were randomly conducted as randomized complete design with 4 treatment and 4 replication. The experimental grou...