PURPOSE The purpose of the present study was to evaluate the anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb), cetuximab, (IMC-C225) and the anti-EGFRvIII mAb, L8A4, used in combination as delivery agents for boron neutron capture therapy (BNCT) of a rat glioma composed of a mixture of cells expressing either wild-type (F98(EGFR)) or mutant receptors(F98(npEGFRvIII)). EX...

Introduction: Recently head and neck cancer has pay attention to many researchers. Its therapeutic methods include surgery, chemotherapy, radiotherapy and Boron neutron capture therapy (BNCT). BNCT is better than conventional radiotherapy because it targets the tumor cell. This method involves two steps of infusion of stable 10B and then neutron radiation with a suitable intens...

Background: The aim of this work was to establish how well gel dosimeters performed, as substitutes for brain tissue compared with standard phantom materials such as water, polymethyl-methacrylate (or PMMA), A150 plastic and TE- liquid phantom material for dosimetry of neutron beams in boron neutron capture therapy. Materials and Methods: Thermal neutron fluence, photon dose and epithermal neu...

An accelerator-based BNCT (Boron Neutron Capture Therapy) facility is being constructed at the Ibaraki Neutron Medical Research Center. It consists of a proton linac of 80kW beam power with 8 MeV energy, a beryllium target, and a moderator system to provide an epithermal neutron flux sufficient for patient treatment. The technology choices for this present system were driven by the need to hous...

Boron neutron capture therapy (BNCT) is a radiotherapy that has mainly been used to treat malignant brain tumours, melanomas, and head and neck cancer. In BNCT, the patient receives an intravenous infusion of a B carrier, which accumulates in the tumour area. The tumour is irradiated with epithermal or thermal neutrons, which result in a boron neutron capture reaction B(n,α)Li. This generates h...

background: a boron neutron capture therapy (bnct) facility, based on a dt neutron generator, with the final goal to find out a potential, alternative, solution to existing bnct treatment facilities which are based on nuclear reactors is examined. materials and methods: with the aim of the mcnp4b monte carlo code different beam-shaping assembly (bsa) configurations were considered. lead was sel...

background: the aim of this work was to establish how well gel dosimeters performed, as substitutes for brain tissue compared with standard phantom materials such as water, polymethyl-methacrylate (or pmma), a150 plastic and te- liquid phantom material for dosimetry of neutron beams in boron neutron capture therapy. materials and methods: thermal neutron fluence, photon dose and epithermal neut...

Background and purpose: Accelerator-Based Boron Neutron Capture Therapy is a radiotherapy based on compact accelerator neutron sources requiring an epithermal field for tumour irradiations. Neutrons of 10 keV are considered as the maximum optimised energy to treat deep-seated tumours. We investigated, by means Monte Carlo simulations, range from eV in order optimise function depth. Methods: A S...