Intact bone tissue exhibits a characteristic anisotropic microstructure derived from collagen fiber alignment and the related c-axis orientation of apatite crystals, which govern the mechanical properties of bone tissue. In contrast, tumor-invaded bone exhibits a disorganized, less-aligned microstructure that results in severely disrupted mechanical function. Despite its importance both in basi...

The attachment of an implant material to bone relates to surface roughness and surface chemistry. There is a relatively low chemical bonding strength of so-called bioactive surfaces. Hydroxyapatite interfaces typically have an interfacial tensile strength of 0.15-1.5 MPa. An attachment force similar to that of bioactive surfaces might also be reached through mechanical interlock with ordinary b...

Here, we present a bone implant system of phase-oriented titanium dioxide (TiO 2 ) fabricated by the micro-arc oxidation method (MAO) on ?-Ti to facilitate improved osseointegration. This (101) rutile-phase-dominant MAO TiO (R-TiO is biocompatible due its high surface roughness, bone-mimetic structure, and preferential crystalline orientation. Furthermore, R-TiO possesses active abundant hydrox...

OBJECTIVES Little biomechanical information is available about kinematically aligned (KA) total knee arthroplasty (TKA). The purpose of this study was to simulate the kinematics and kinetics after KA TKA and mechanically aligned (MA) TKA with four different limb alignments. MATERIALS AND METHODS Bone models were constructed from one volunteer (normal) and three patients with three different k...

Previous studies have shown that bone marrow, especially the bone microenvironment, may play an important role in the pathogenesis of multiple myeloma (MM). To elucidate the relationship between myeloma cells and bone cells, mainly osteoblasts, we have established a coculture system between two interleukin-6 (IL-6)-dependent myeloma cell lines, XG1 and XG6, and the osteosarcoma cell lines Saos-...

There was no evidence of osteonecrosis in the specimens analysed. The hydroxyapatite-coating was present to a variable degree on the specimens with good evidence of bony ongrowth under the CoChrome cap. Ongrowth was examined in five different zones with the greatest seen in the middle of the stem. Direct contact between newly formed bone and the hydroxyapatite layer was observed on light and ba...

Implants were placed in the femurs of miniature pigs. After 3 and 6 weeks respectively, the implants were removed and analyzed. Signifi cant differences were noted in the percentage of B.I.C. (Bone Implant Contact). Polished, sandblasted with fi ne grit, or acid etched implant surfaces had the lowest percentage of B.I.C. (B.I.C. < 25%). Grit-blasted (coarse grit) or T.P.S. (Titanium Plasma Spra...

  Objective: Alveolar ridge preservation in patients with inadequate bone volume is one treatment option for successful implant placement and can be done by using bone graft materials. On the other hand, Ceno Bone has been recently produced by Hamanand Saz Baft Kish Co. as a bone bioimplant of allograft origin. This study aimed to assess the clinical, histologic and histomorphometric results of...

background: the success of dental implants depends on the manner in which stresses are transferred to the surrounding bone. an important consideration is to design an implant with a geometry that will minimize the peak bone stresses caused by standard loading. the aim of this study was to assess the infl uence of implant thread geometry on biomechanical load transfer and to compare the differen...

Bulk allograft reconstruction plays an important role in limb-salvage reconstructive surgery but is complicated by nonunion in up to one-third of cases. Because allograft-host healing is mediated via creeping substitution, intimate bone contact is desirable. Intraoperative assessment and optimization of the allograft-host junction site using a conventional transverse osteotomy is challenging an...