Although for many decades bisphosphonates were used for adult bone loss, bisphosphonate administration in pediatric patients is new and was initiated in the past 15-year. The indications for pediatric bisphosphonates was extended to childhood malignancies with bone involvement, after additional effects were unveiled for bisphosphonates with recent research. In this article we review childhood b...

Bone metastasis alone without involvement of bone marrow is rarely seen in primary breast lymphoma (PBL). It has a poor prognosis. A 64-years old woman was diagnosed as high-grade PBL T type. The patient received 6 sessions of chemotherapy with a diagnosis of stage IIAE PBL. The patient achieved remission and was followed for 12 years. She underwent surgery due to fracture at lower half of righ...

Granulocytic sarcoma is a tumor consisting of myeloid blasts with or without maturation that occurs at an anatomical site other than bone marrow. Most frequently affected sites are skin, lymph nodes, gastrointestinal tract, bone, soft tissue and testes. AML may manifest as granulocytic sarcoma at diagnosis or relapse. Although it has been considered to be rare relapse as granulocytic sarcoma af...