Papillary thyroid carcinoma (PTC) is one of the most commonly diagnosed types of differentiated carcinoma of the thyroid. It is stated that lung is the most common site of metastasis followed by bone. The incidence of paranasal sinus (PNS) metastasis is fairly uncommon in case of thyroid carcinoma. To the best of our knowledge, no case of metastatic PTC to nasal cavity has been reported. In thi...

Mice with a targeted deletion of beta3 integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of beta3+/+ mice by 14 days. In contrast, only 4% of beta3-/- mice developed bone lesions. Direct intratibial inoculation of tumor resulted in marrow repla...

Hepatocellular carcinoma is the most common primary liver tumor. usually makes metastasis to bones. Prognosis of bone hepatocellular becoming better with early diagnosis and improvements in treatment modalities. As survival increases, faced more. However, humerus very rare. Bone may result symptoms pathologic fractures. worsens patients’ quality life. Early proper are important. Herein we repor...

With rising incidence of breast carcinoma in Asian population, staging workup remains a crucial entity diseasemanagement and outcome. Bone scintigraphy for detection osteoblastic metastasis has remained convenient choice.However, the presence underlying lytic bony lesions sensitivity 99mTc-MDP bone scan is questionable when comparedto 18F-FDG PET-CT scan. We present case that showed better pick...

Background: Lung cancer is the most common cause of cancer death worldwide with an annual mortality rate of more than 1.3 million worldwide. We aimed to analyze the clinicopathological features of patients with non-small-cell lung cancer (NSCLC) in west of Iran. Methods: 64 patients with NSCLC who referred to our clinic were analyzed. Sex, age, histopathology, location of the tumor, treatment,...

www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. Targeting bone metastases in prostate cancer (PCa) is a major goal since bone metastases are present in >90% of advanced PCa patients causing significant morbidity and mortality (1). Treatment strategies used for “bone targeted” therapies including bisphosphonates and radionuclides mainly focused on the treatment of e...

CD47, also called integrin-associated protein, plays a critical role in the innate immune response and is an atypical member of the immunoglobulin superfamily that interacts with and activates beta3 integrins. beta3 integrin(-/-) mice have defective platelet and osteoclast function and are protected from bone metastasis. The role of CD47 in skeletal homeostasis and bone metastasis has not been ...

Objective The prognosis for renal cell carcinoma (RCC) is related to a high rate of metastasis, including 30% of bone metastasis. In this study, we investigate the correlation between diverse clinical factors and bone metastases secondary from renal cell cancer (RCC), and to identify potential risk factors for bone metastasis in newly diagnosed patients and those who have already received treat...

OBJECTIVE Typically, bone metastasis causes osteolytic and osteoblastic lesions resulting from the interactions of tumor cells with osteoclasts and osteoblasts. In addition to these interactions, tumor tissues may grow inside bones and cause mass lesions. In the present study, we aimed to demonstrate the negative impact of a tumor mass in a large cohort of patients with bone metastatic cancer. ...

Renal cell carcinoma comprises about 2% of adult tumors. The overall 10-year survival rate of patients with RCC after nephrectomy is about 18-27%. The incidence of metastasis of initial RCC is about 24-28%, but this rate after nephrectomy is as high as 51%. The most common site of recurrence is the lung, however liver and bone metastases are common.There are many reported cases with late metast...