conclusions prominent musculoskeletal complaints (especially back pain) accompanied by constitutional symptoms such as fever, malaise and weight loss may be consistent with brucellosis. introduction species of bacteria brucellosis, which can infect humans, are brucella abortus, b melitensis, b. suis and rarely b. canis. case presentation a 71-year-old woman with severe pain in the limbs, especi...

One month later the patient received 4.22 GBq (114 mCi) 153Samarium-EDTMP for palliation of severe bone pain. Post treatment, whole body 153Samarium scan was also a “superscan” showing very similar osseous metastases pattern to the 99mTc-MDP bone scan. Anterior and posterior whole body images 24 hours after intravenous administration of 153Sm-EDTMP demonstrate diffuse osseous metastases in a ve...

Copyright © 2016 Xue-Jun Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer pain possesses a major challenge in clinical treatment , yet its underlying mechanisms remain elusive. Recent advances in understanding th...

BACKGROUND Beliefs of caregivers about patient's pain have been shown to influence assessment and treatment of children's pain, now considered an essential part of cancer treatment. Painful procedures in hematology-oncology are frequently referred by children as the most painful experiences during illness. Aim of this study was to evaluate professionals' beliefs about painfulness of invasive pr...

Introduction:The use of beta emitters is one of the effective methods for palliation of bone metastasis. The risk of normal tissue toxicity should be evaluated in the bone pain palliation treatment. Methods: In this study, the Monte Carlo simulation code MCNPX was used for simulation a bone phantom model consisted of bone marrow, bone and soft tissue. Spe...

83 Cole BJ, Harris JD, eds. Biologic Knee Reconstruction: A Surgeon’s Guide (pp 83-89). © 2015 SLACK Incorporated. Focal chondral defects and osteoarthritis are common causes of knee pain. Isolated articular cartilage lesions may progress, in size and symptoms, to degenerative arthritis. The biochemical and biomechanical relationships between articular cartilage and underlying subchondral bone ...

Pain often accompanies cancer and most current therapies for treating cancer pain have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropomyosin receptor kinase A (TrkA) has become an attractive target for attenuating chronic pain. In the present report, we use a mouse model of bone cancer pain and examine whether oral administration of a selecti...

This study is to establish a model of rat tibial osteocarcinoma pain, intrathecally inject specific ERK1/2 inhibitors SCH772984, observe the analgesic effect, and discuss the influence of ERK-P90RSK-Fos signal path in bone cancer pain. Forty female SD rats were randomly divided into 5 groups. Establish a bone cancer pain model after putting the intrathecal tube 5d and determine the rats' mechan...

Objective(s): As heat, pain is one of the most common clinical symptoms. Generally, calcitonin (CT) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. However, the detailed mechanism remains unknown.Materials and Methods: In this study, chronic constriction injury (CCI) rat model was created, and ho...

Background: Rupture of anterior cruciate ligament (ACL) would cause instability and disability and if left untreated. Reconstruction is performed by different techniques including patellar bone graft, as the strongest device. Application of brace after ACL reconstructions has revealed doubtful results. Methods: One hundred ACL ruptured patients randomized into two groups were reconstructed with...