By H. S. WINCHELL, MYRON POLLYCOVE, W. D. LOUGHMAN AND J. H. LAWRENCE R ELATIVELY selective beta irradiation of the lymphatic system in the dog has been achieved with internally administered Yttrium90 chelated with diethylene triamine penta-acetic acid ( Y90-DTPA) . Intravenous injection of Y#{176}#{176}-DTPA followed by continuous intravenous infusion of the animal’s own urine containing the e...

Bone marrow transplantation in man.-Georges Math#{233} ( Paris ) opened the discussion by reviewing the Yugoslavian reactor accident and discussing the clinical management of the exposed individuals. Adult homologous bone marrow or homologous fetal liver was used to treat five of the victims. One man died and the others survived with evidence of temporary transplantation of red blood cell-formi...

Over the last 20 years allogeneic bone marrow transplantation from an HLA-identical sibling donor has become the treatment of choice for a number of human haematological malignancies, severe aplastic anaemia, some congenital diseases of the immune and haemopoietic systems, and some inborn errors of metabolism. Recently, the successful introduction of HLA-matched unrelated donor transplants, con...

OBJECTIVE To study the efficacy of bone marrow mesenchymal stem cell (MSC) transplantation to treat pulmonary emphysema in rats. METHODS Sixty rats were randomly divided into control, model and transplantation groups. Each group contained 20 rats. Rat models of emphysema were established via intratracheal instillation of lipopolysaccharide and exposure of model and transplantation groups to s...

By H. S. WINCHELL, MYRON POLLYCOVE, W. D. LOUGHMAN AND J. H. LAWRENCE R ELATIVELY selective beta irradiation of the lymphatic system in the dog has been achieved with internally administered Yttrium90 chelated with diethylene triamine penta-acetic acid ( Y90-DTPA) . Intravenous injection of Y#{176}#{176}-DTPA followed by continuous intravenous infusion of the animal’s own urine containing the e...

Bone marrow transplantation in man.-Georges Math#{233} ( Paris ) opened the discussion by reviewing the Yugoslavian reactor accident and discussing the clinical management of the exposed individuals. Adult homologous bone marrow or homologous fetal liver was used to treat five of the victims. One man died and the others survived with evidence of temporary transplantation of red blood cell-formi...

Bone marrow transplantation in man.-Georges Math#{233} ( Paris ) opened the discussion by reviewing the Yugoslavian reactor accident and discussing the clinical management of the exposed individuals. Adult homologous bone marrow or homologous fetal liver was used to treat five of the victims. One man died and the others survived with evidence of temporary transplantation of red blood cell-formi...

Allogeneic bone marrow transplantation (BMT) after high-dose, marrow-ablative chemoradiotherapy has been established as the treatment of choice for various hematologic, neoplastic, and congenital disorders. The most common type of marrow graft is an allogeneic one from a sibling donor who has compatible human leukocyte antigen (HLA). Only 30% of patients requiring allogeneic BMT have an HLA-com...

B ONE MARROW TRANSPLANTATION may effectively protect dogs exposed to whole-body ionizing radiations of 2 to 3 LD95. Hematopoiesis was investigated at remote periods after the exposure, when the hematopoietic stem cells had been proliferating in the lethally irradiated organism for a long time. Ferrebee and his associates’6 succeeded in attaining long-term survival of supralethally irradiated do...

A 1 3-yr-old male with acute myelogenous therapy. Then, 53 yr later, he developed leukemia was treated with various chemoan extramedullary relapse with a chlotherapy regimens for 3 yr and then underroma of his maxillary sinus. This case ilwent an allogeneic bone marrow translustrates the need for prolonged followup plantation. The donor marrow was sucof transplant recipients and suggests that c...