The hypothesis that bone marrow-derived, circulating endothelial cells incorporate into tumor blood vessels is unresolved. We have measured the numbers of bone marrow-derived versus resident endothelial cells in spontaneous prostate cancers during different stages of tumor progression and in age-matched normal prostates. Bone marrow-derived endothelial cells were rare in dysplasia and in well d...

Bone tumors are deadly and incurable diseases that invade large areas of bone, resulting in bone defects. Traditional therapies combining surgery, chemotherapy, radiation have reached their limit efficacy, motivating efforts to develop new therapeutic methods. Fortunately, the development biomaterials provides innovative options for tumor treatment. Suitable capable simultaneously providing the...

CD47, also called integrin-associated protein, plays a critical role in the innate immune response and is an atypical member of the immunoglobulin superfamily that interacts with and activates beta3 integrins. beta3 integrin(-/-) mice have defective platelet and osteoclast function and are protected from bone metastasis. The role of CD47 in skeletal homeostasis and bone metastasis has not been ...

BACKGROUND Most patients with advanced breast cancer develop bone metastases, which cause pain, hypercalcemia, fractures, nerve compression and paralysis. Chemotherapy causes further bone loss, and bone-specific treatments are only palliative. Multiple tumor-secreted factors act on the bone microenvironment to drive a feed-forward cycle of tumor growth. Effective treatment requires inhibiting u...

Introduction: A keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. It represents 2–11% of jaw cysts, and has a slow but aggressive growth. The evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesion...

Thrombocytopenia is a common manifestation of tumors, which usually caused by myelosuppression bone marrow involvement malignant tumor cells or radiotherapy. Immune thrombocytopenia (ITP), as paraneoplastic syndrome, more in lymphatic proliferative neoplasms and rheumatic diseases, less solid neoplasms, has not been reported peritoneal epithelioid mesothelioma.Herein, we report 45-year-old pati...

Osteoma is an uncommon bone tumor in avian species and other animals. A 2-year-old male canary (Serinus canaria) with a history of an oval mass in the left wing for several months was examined. Radiographs showed a radio-opaque mass. Upon the bird’s owner request, the canary was euthanatized and submitted for necropsy. The histopathologic examination revealed numerous trabeculae consis...

Skeletal metastases are frequent complications of many cancers, causing bone (fractures, pain, disability) that negatively affect the patient’s quality life. Here, we first discuss burden skeletal in cancer metastasis. We then describe pathophysiology Bone metastasis is a multistage process: long before development clinically detectable metastases, circulating tumor cells settle and enter dorma...

We have previously shown that a transplantable murine tumor (CE mammary carcinoma) causes marked neutrophilia and excessive bone resorption in vivo. In order to understand the humoral mechanism of these tumor-induced phenomena, we successfully established a cell line (CE 816) and subsequently cloned CE mammary carcinoma cells in serum-free culture conditions. Cultured CE tumor cells continued t...