PURPOSE The aim of this work was to determine dose distributions for high-energy brachytherapy sources at spatial locations not included in the radial dose function gL(r) and 2D anisotropy function F(r,θ) table entries for radial distance r and polar angle θ. The objectives of this study are as follows: 1) to evaluate interpolation methods in order to accurately derive gL(r) and F(r,θ) from the...

Higher initial dose rate and simplifying HDR room treatment of 169Yb element among other brachytherapy sources has led to investigating its feasibility as high-dose-rate seed. In this work, Monte Carlo calculation was performed to obtain dosimetric parameters of 169Yb, Model M42 source at different radial distances according to AAPM TG-43U1 and HEBD Report about HDR sources in both air vacuum a...

RATIONALE The E2F pathway plays a critical role in cardiac growth and development, yet its role in cardiac metabolism remains to be defined. Metabolic changes play important roles in human heart failure and studies imply the ketogenic enzyme β-hydroxybutyrate dehydrogenase I (BDH1) is a potential biomarker. OBJECTIVE To define the role of the E2F pathway in cardiac metabolism and dilated card...

Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43). To investigate in depth the behavioral phenotype associated with this proteinopathy, we used as a model transgenic (Tg) mice conditionally overexpressing human wild-type TDP 43 protein (hTDP-43-WT) in foreb...

Due to a number of distinct advantages resulting from the relatively low energy gamma ray spectrum of Yb-169, various designs of Yb-169 sources have been developed over the years for brachytherapy applications. Lately, Yb-169 has also been suggested as an effective and practical radioisotope option for a novel radiation treatment approach often known as gold nanoparticle-aided radiation therapy...

The American Association of Physicists in Medicine (AAPM) formed Task Group 178 (TG-178) to perform the following tasks: review in-phantom and in-air calibration protocols for gamma stereotactic radiosurgery (GSR), suggest a dose rate protocol that can be successfully utilized with all (GSR) devices, update quality assurance (QA) TG-42 (AAPM Report 54, 1995) static GSR devices. TG-178 report re...

*Corresponding author: Dr. Mohammad Amin Mosleh-Shirazi, Department of Radiotherapy and Oncology, Shiraz University of Medical Sciences, Shiraz, Iran. Fax: +98 711 6474320 E-mail: [email protected] Background: The dose rate distribution delivered by a low dose rate 137Cs pellet source, a spherical source used within the source trains of the Selectron gynecological brachytherapy system, was inv...

31 The role of cardiac myosin essential light chain (ELC) in the sarcomere length (SL)-dependency 32 of myofilament contractility is unknown. Therefore, mechanical and dynamic contractile 33 properties were measured at SL 1.9 μm and 2.2 μm in cardiac muscle fibers from two groups of 34 transgenic (Tg) mice: 1) Tg-wild type (WT) mice that expressed wild type human ventricular 35 ELC; and 2) Tg-Δ...

For nonpolymeric supercooled liquids, the empirical correlation m = 56Tg DeltaCp(Tg)/DeltaHm provides a reliable means of correlating dynamic and thermodynamic variables. The dynamics are characterized by the fragility or steepness index m and the glass transition temperature Tg, while thermodynamics enter in terms of the heat capacity step DeltaCp at Tg and the melting enthalpy DeltaHm. The co...