BACKGROUND This study was designed to obtain the chemical fingerprint and to investigate the effect of Phyllanthus urinaria on telomerase activity and apoptotic pathways in the human nasopharyngeal carcinoma cell line (NPC-BM1). MATERIALS AND METHODS The polyphenol compounds in P. urinaria were investigated by HPLC/MS. Cell viability with the treatment of P. urinaria, gallic acid, ellagic aci...

antioxidants have protective effects against free radicals-induced neural damage in parkinson's disease (pd). we examined the effects of ellagic acid (ea) on locomotion, pallidal local eeg, and its frequency bands' power and also cerebral antioxidant contents in a rat model of pd induced by 6-hydroxidopamine (6-ohda). 6-ohda (16 µg/2µ l) was injected into the right medial forebrain bundle (mfb)...

There is currently a shifting focus towards finding natural compounds that may prevent or treat cancer, due to the problems that exist with current chemotherapeutic regimens. The fruit of the Punica granatum (pomegranate) contains hundreds of phytochemicals and pomegranate extracts have recently been shown to exhibit antioxidant properties, thought to be due to the action of ellagic acid, the m...

Gallic acid (GA), rutin(R), quercitin (Q), ellagic acid (EA) and sitosterol(S) isolated from the methanolic extract of the leaves of Tectona grandis were formulated as 0.2 % ointment in emulsifying base and were evaluated for their wound healing activity. The animals were divided into eight groups of six animals each. Groups 1 used as control, group 2 used as a standard i.e. nitrofurazone ointm...

ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. twenty–four male wistar rats (250-300 g body wt) were used in this study. the animals were divided into four groups of 6 rat...

Introduction: There are several different molecular pathways in tissue damage by Ischemic Brain Injury. The use of antioxidants and free radical scavengers are a matter of attention by some researchers. Crocus sativus (saffron) is used previously for protective effects in ischemia state by some researchers. To assess pathologic aspects of neuroprotection of saffron in some susceptible brain are...

In the paper entitled " A comparative study for the evaluation of two doses of ellagic acid on hepatic drug metabolizing and antioxidant enzymes in the rat " , there was an error in Figure 4, and here we provide the right form of Figure 4.

background and objective: as one of the widely used drugs, aspirin (acetyl-salicylic acid, asa) plays an important role in stroke treatment and prevention. in a previous study, we demonstrated asa injection at 30 min after ischemia onset is neuroprotective. to determine whether the neurons protected by asa had a normal ultrastructure, hippocampal ca1 pyramidal neurons were examined by transmiss...